Robert K. Shepherd

Publications

• Evaluation of Focused Multipolar Stimulation for Cochlear Implants in Long-term Deafened Cats
  Journal of Neural Engineering. Apr, 2015  |   Pubmed ID: 25834113
• Infrared Neural Stimulation Fails to Evoke Neural Activity in the Deaf Guinea Pig Cochlea
  Hearing Research. Mar, 2015  |   Pubmed ID: 25796297
• Cell-based Neurotrophin Treatment Supports Long-term Auditory Neuron Survival in the Deaf Guinea Pig
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2015  |   Pubmed ID: 25481440
• First-in-human Trial of a Novel Suprachoroidal Retinal Prosthesis
  PloS One. 2014  |   Pubmed ID: 25521292
• ATP-induced Photoreceptor Death in a Feline Model of Retinal Degeneration
  Investigative Ophthalmology & Visual Science. Dec, 2014  |   Pubmed ID: 25425300
• Evaluation of Focused Multipolar Stimulation for Cochlear Implants in Acutely Deafened Cats
  Journal of Neural Engineering. Dec, 2014  |   Pubmed ID: 25420148
• In Vivo and in Vitro Comparison of the Charge Injection Capacity of Platinum Macro Electrodes
  IEEE Transactions on Bio-medical Engineering. Nov, 2014  |   Pubmed ID: 25376031
• Mold-templated Inorganic-organic Hybrid Supraparticles for Codelivery of Drugs
  Biomacromolecules. Nov, 2014  |   Pubmed ID: 25321318
• Safety and Efficacy of Explanting or Replacing Suprachoroidal Electrode Arrays in a Feline Model
  Clinical & Experimental Ophthalmology. Sep, 2014  |   Pubmed ID: 25196241
• Mesoporous Silica Supraparticles for Sustained Inner-ear Drug Delivery
  Small (Weinheim an Der Bergstrasse, Germany). Nov, 2014  |   Pubmed ID: 25099026
• Cortical Activation Following Chronic Passive Implantation of a Wide-field Suprachoroidal Retinal Prosthesis
  Journal of Neural Engineering. Aug, 2014  |   Pubmed ID: 24965866
• Effects of Deafness and Cochlear Implant Use on Temporal Response Characteristics in Cat Primary Auditory Cortex
  Hearing Research. Sep, 2014  |   Pubmed ID: 24933111
• Chronic Electrical Stimulation with a Suprachoroidal Retinal Prosthesis: a Preclinical Safety and Efficacy Study
  PloS One. 2014  |   Pubmed ID: 24853376
• Gene Therapy Boosts the Bionic Ear
  Science Translational Medicine. Apr, 2014  |   Pubmed ID: 24760187
• Measurement of Forces at the Tip of a Cochlear Implant During Insertion
  IEEE Transactions on Bio-medical Engineering. Apr, 2014  |   Pubmed ID: 24658242
• Development of a Surgical Procedure for Implantation of a Prototype Suprachoroidal Retinal Prosthesis
  Clinical & Experimental Ophthalmology. Sep-Oct, 2014  |   Pubmed ID: 24330322
• Effects of Chronic Cochlear Electrical Stimulation After an Extended Period of Profound Deafness on Primary Auditory Cortex Organization in Cats
  The European Journal of Neuroscience. Mar, 2014  |   Pubmed ID: 24325274
• Visual Prostheses for the Blind
  Trends in Biotechnology. Oct, 2013  |   Pubmed ID: 23953722
• Suprachoroidal Electrical Stimulation: Effects of Stimulus Pulse Parameters on Visual Cortical Responses
  Journal of Neural Engineering. Oct, 2013  |   Pubmed ID: 23928717
• A Wide-field Suprachoroidal Retinal Prosthesis is Stable and Well Tolerated Following Chronic Implantation
  Investigative Ophthalmology & Visual Science. Apr, 2013  |   Pubmed ID: 23611996
• Chronic Neurotrophin Delivery Promotes Ectopic Neurite Growth from the Spiral Ganglion of Deafened Cochleae Without Compromising the Spatial Selectivity of Cochlear Implants
  The Journal of Comparative Neurology. Aug, 2013  |   Pubmed ID: 23436344
• Challenges for Stem Cells to Functionally Repair the Damaged Auditory Nerve
  Expert Opinion on Biological Therapy. Jan, 2013  |   Pubmed ID: 23094991
• Neurotrophin Gene Therapy for Sustained Neural Preservation After Deafness
  PloS One. 2012  |   Pubmed ID: 23284995
• Hydrogel Limits Stem Cell Dispersal in the Deaf Cochlea: Implications for Cochlear Implants
  Journal of Neural Engineering. Dec, 2012  |   Pubmed ID: 23186887
• Special Section on Medical Bionics
  Journal of Neural Engineering. Dec, 2012  |   Pubmed ID: 23186858
• Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration
  Advanced Materials (Deerfield Beach, Fla.). Jul, 2012  |   Pubmed ID: 22610659
• Visual Cortex Responses to Suprachoroidal Electrical Stimulation of the Retina: Effects of Electrode Return Configuration
  Journal of Neural Engineering. Jun, 2012  |   Pubmed ID: 22595310
• Development of a Surgical Approach for a Wide-view Suprachoroidal Retinal Prosthesis: Evaluation of Implantation Trauma
  Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Mar, 2012  |   Pubmed ID: 21874343
• Combining Cell-based Therapies and Neural Prostheses to Promote Neural Survival
  Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2011  |   Pubmed ID: 21904788
• Spiral Ganglion Neuron Survival and Function in the Deafened Cochlea Following Chronic Neurotrophic Treatment
  Hearing Research. Dec, 2011  |   Pubmed ID: 21762764
• The Effect of Deafness Duration on Neurotrophin Gene Therapy for Spiral Ganglion Neuron Protection
  Hearing Research. Aug, 2011  |   Pubmed ID: 21557994
• Enhanced Auditory Neuron Survival Following Cell-based BDNF Treatment in the Deaf Guinea Pig
  PloS One. 2011  |   Pubmed ID: 21525998
• An Automated System for Rapid Evaluation of High-density Electrode Arrays in Neural Prostheses
  Journal of Neural Engineering. Jun, 2011  |   Pubmed ID: 21493979
• Pneumococcal Meningitis Post-cochlear Implantation: Preventative Measures
  Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Nov, 2010  |   Pubmed ID: 20970694
• Pneumococcal Meningitis Post-cochlear Implantation: Potential Routes of Infection and Pathophysiology
  Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Nov, 2010  |   Pubmed ID: 20970686
• Examining the Auditory Nerve Fiber Response to High Rate Cochlear Implant Stimulation: Chronic Sensorineural Hearing Loss and Facilitation
  Journal of Neurophysiology. Dec, 2010  |   Pubmed ID: 20926607
• Bilateral Cochlear Implantation in the Ferret: a Novel Animal Model for Behavioral Studies
  Journal of Neuroscience Methods. Jul, 2010  |   Pubmed ID: 20576507
• Evaluation of Stimulus Parameters and Electrode Geometry for an Effective Suprachoroidal Retinal Prosthesis
  Journal of Neural Engineering. Jun, 2010  |   Pubmed ID: 20479521
• Effects of Localized Neurotrophin Gene Expression on Spiral Ganglion Neuron Resprouting in the Deafened Cochlea
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2010  |   Pubmed ID: 20216530
• Special Issue on Medical Bionics
  Journal of Neural Engineering. Dec, 2009  |   Pubmed ID: 19861723
• Neural Prostheses and Brain Plasticity
  Journal of Neural Engineering. Dec, 2009  |   Pubmed ID: 19850976
• Effects of Neonatal Partial Deafness and Chronic Intracochlear Electrical Stimulation on Auditory and Electrical Response Characteristics in Primary Auditory Cortex
  Hearing Research. Nov, 2009  |   Pubmed ID: 19703532
• Cochlear Implant Use Following Neonatal Deafness Influences the Cochleotopic Organization of the Primary Auditory Cortex in Cats
  The Journal of Comparative Neurology. Jan, 2009  |   Pubmed ID: 18972570
• A Protocol for Cryoembedding the Adult Guinea Pig Cochlea for Fluorescence Immunohistology
  Journal of Neuroscience Methods. Jan, 2009  |   Pubmed ID: 18835298
• Promoting Neurite Outgrowth from Spiral Ganglion Neuron Explants Using Polypyrrole/BDNF-coated Electrodes
  Journal of Biomedical Materials Research. Part A. Oct, 2009  |   Pubmed ID: 18814235
• The Auditory Brain--a Tribute to Dexter R.F. Irvine
  Hearing Research. Apr, 2008  |   Pubmed ID: 18291607
• Neurotrophins and Electrical Stimulation for Protection and Repair of Spiral Ganglion Neurons Following Sensorineural Hearing Loss
  Hearing Research. Aug, 2008  |   Pubmed ID: 18243608
• Can We Prevent Cochlear Implant Recipients from Developing Pneumococcal Meningitis?
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jan, 2008  |   Pubmed ID: 18171202
• Cochlear Implants Stimulate Activity-dependent CREB Pathway in the Deaf Auditory Cortex: Implications for Molecular Plasticity Induced by Neural Prosthetic Devices
  Cerebral Cortex (New York, N.Y. : 1991). Aug, 2008  |   Pubmed ID: 18063565
• Cochlear Implants and Brain Plasticity
  Hearing Research. Apr, 2008  |   Pubmed ID: 17910997
• Meningitis After Cochlear Implantation
  BMJ (Clinical Research Ed.). Nov, 2007  |   Pubmed ID: 18033888
• Assessment of the Protective Effect of Pneumococcal Vaccination in Preventing Meningitis After Cochlear Implantation
  Archives of Otolaryngology--head & Neck Surgery. Oct, 2007  |   Pubmed ID: 17938321
• A Fully Implantable Stimulator for Use in Small Laboratory Animals
  Journal of Neuroscience Methods. Nov, 2007  |   Pubmed ID: 17897719
• Schwann Cells Revert to Non-myelinating Phenotypes in the Deafened Rat Cochlea
  The European Journal of Neuroscience. Oct, 2007  |   Pubmed ID: 17868369
• Concise Review: the Potential of Stem Cells for Auditory Neuron Generation and Replacement
  Stem Cells (Dayton, Ohio). Nov, 2007  |   Pubmed ID: 17656641
• Deafness Alters Auditory Nerve Fibre Responses to Cochlear Implant Stimulation
  The European Journal of Neuroscience. Jul, 2007  |   Pubmed ID: 17650121
• Mice Deficient for the Type II Transmembrane Serine Protease, TMPRSS1/hepsin, Exhibit Profound Hearing Loss
  The American Journal of Pathology. Aug, 2007  |   Pubmed ID: 17620368
• Neurotrophic Factors and Neural Prostheses: Potential Clinical Applications Based Upon Findings in the Auditory System
  IEEE Transactions on Bio-medical Engineering. Jun, 2007  |   Pubmed ID: 17551571
• Threshold Shift: Effects of Cochlear Implantation on the Risk of Pneumococcal Meningitis
  Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Apr, 2007  |   Pubmed ID: 17418257
• Effects of Inner Ear Trauma on the Risk of Pneumococcal Meningitis
  Archives of Otolaryngology--head & Neck Surgery. Mar, 2007  |   Pubmed ID: 17372082
• Does Cochlear Implantation and Electrical Stimulation Affect Residual Hair Cells and Spiral Ganglion Neurons?
  Hearing Research. Mar, 2007  |   Pubmed ID: 17258411
• Protective Effects of Local Administration of Ciprofloxacin on the Risk of Pneumococcal Meningitis After Cochlear Implantation
  The Laryngoscope. Dec, 2006  |   Pubmed ID: 17146386
• Pneumococcal Meningitis Threshold Model: A Potential Tool to Assess Infectious Risk of New or Existing Inner Ear Surgical Interventions
  Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Dec, 2006  |   Pubmed ID: 16980916
• Pneumococcal Meningitis: Development of a New Animal Model
  Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Sep, 2006  |   Pubmed ID: 16936571
• Basis of Electrical Stimulation of the Cochlea and the Cochlear Nucleus
  Advances in Oto-rhino-laryngology. 2006  |   Pubmed ID: 16891843
• Aminoglycoside-induced Degeneration of Adult Spiral Ganglion Neurons Involves Differential Modulation of Tyrosine Kinase B and P75 Neurotrophin Receptor Signaling
  The American Journal of Pathology. Aug, 2006  |   Pubmed ID: 16877354
• Effect of Interphase Gap and Pulse Duration on Electrically Evoked Potentials is Correlated with Auditory Nerve Survival
  Hearing Research. May, 2006  |   Pubmed ID: 16644157
• Clinical Application of Neurotrophic Factors: the Potential for Primary Auditory Neuron Protection
  The European Journal of Neuroscience. Nov, 2005  |   Pubmed ID: 16262651
• Survival of Partially Differentiated Mouse Embryonic Stem Cells in the Scala Media of the Guinea Pig Cochlea
  Journal of the Association for Research in Otolaryngology : JARO. Dec, 2005  |   Pubmed ID: 16208453
• Exogenous BDNF Rescues Rat Spiral Ganglion Neurons in Vivo
  Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. Sep, 2005  |   Pubmed ID: 16151360
• Cochlear Implantation in Rats: a New Surgical Approach
  Hearing Research. Jul, 2005  |   Pubmed ID: 15953521
• Chronic Depolarization Enhances the Trophic Effects of Brain-derived Neurotrophic Factor in Rescuing Auditory Neurons Following a Sensorineural Hearing Loss
  The Journal of Comparative Neurology. May, 2005  |   Pubmed ID: 15844207
• Long-term Sensorineural Hearing Loss Induces Functional Changes in the Rat Auditory Nerve
  The European Journal of Neuroscience. Dec, 2004  |   Pubmed ID: 15579167
• Surface Microstructure of the Perilymphatic Space: Implications for Cochlear Implants and Cell- or Drug-based Therapies
  Archives of Otolaryngology--head & Neck Surgery. May, 2004  |   Pubmed ID: 15148170
• Cochlear Immunochemistry--a New Technique Based on Gelatin Embedding
  Journal of Neuroscience Methods. Oct, 2003  |   Pubmed ID: 12951235
• A Multichannel Scala Tympani Electrode Array Incorporating a Drug Delivery System for Chronic Intracochlear Infusion
  Hearing Research. Oct, 2002  |   Pubmed ID: 12361871
• Chronic Placental Insufficiency Has Long-term Effects on Auditory Function in the Guinea Pig
  Hearing Research. Apr, 2002  |   Pubmed ID: 12062768