Rosy Joshi-Mukherjee

Biomedical Engineering

University of Wisconsin-Milwaukee

Rosy Joshi-Mukherjee
Adjunct Professor

Rosy Joshi-Mukherjee is an Adjunct Professor in the Biomedical Engineering Department, College of Engineering and Applied Science, University of Wisconsin in Milwaukee, Wisconsin. She received her PhD in Pharmacology from SUNY Upstate Medical University in Syracuse, New York.

Rosy Joshi-Mukherjee’s scientific interests are to understand cardiomyocyte maturation and cardiotoxicity. Employing multielectrode array technology she discovered an approach to gain intracellular access for recurrent action potential (AP) recordings from the same preparation over days. A comprehensive investigation of the waveform analysis for various AP duration parameters will provide insight in our understanding of cardiomyocyte maturation and cardiotoxicity. As a post-doctoral fellow (2009 to 2014) in the cardiac bioelectric systems laboratory of Dr. Leslie Tung and calcium signals laboratory Dr. David Yue, in the Biomedical Engineering Department (BME) at Johns Hopkins University (JHU), she developed a 2D adult heart cell culture model to understand the arrhythmogenic effect of Timothy Syndrome mutations. In 2014 she received the Ruth L. Kirschstein National Research Service Award at the Heart and Vascular Institute, Division of Cardiology and moved to Dr. Gordon Tomaselli’s laboratory to generate human-induced pluripotent stem cells from patients harboring sodium channel mutation associated with LQT syndrome.

Dr. Joshi-Mukherjee received several research awards from Aurora Research Foundation, Advocate Aurora Healthcare, Milwaukee, Wisconsin to establish hiPSC research program and employ MEA platform for high-throughput AP measurements for reliable electrophysiological investigations.


Human iPSC-Derived Cardiomyocyte Networks on Multiwell Micro-electrode Arrays for Recurrent Action Potential Recordings

1Aurora Research Institute, Advocate Aurora Health Care, 2Department of Biomedical Engineering, College of Engineering and Applied Science, University of Wisconsin-Milwaukee, 3Department of Medicine-Cardiovascular, School of Medicine, Johns Hopkins University

JoVE 59906