In JoVE (1)

Other Publications (19)

Articles by Sara Savelli in JoVE

 JoVE Bioengineering

Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications

1Dept. of Clinical and Experimental Medicine, University of Pisa, 2OtoLab, Azienda Ospedaliero-Universitaria Pisana (AOUP), 3Dept. of Civil and Industrial Engineering, University of Pisa, 4Immunohematology Operative Unit, Azienda Ospedaliero-Universitaria Pisana (AOUP), 5Dept. Of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa, 6II Orthopedic and Traumatologic Clinic, Azienda Ospedaliero-Universitaria Pisana (AOUP)

JoVE 54845

Other articles by Sara Savelli on PubMed

MRI with Diffusion-weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) Assessment in the Evaluation of Normal and Abnormal Fetal Kidneys: Preliminary Experience

Prenatal Diagnosis. Dec, 2007  |  Pubmed ID: 17849498

To investigate apparent diffusion coefficient (ADC) mapping with the measurement of renal tissue ADC value of normal and pathological fetal kidneys at various gestational ages (GAs).

Potential Role of Fetal Cardiac Evaluation with Magnetic Resonance Imaging: Preliminary Experience

Prenatal Diagnosis. Feb, 2008  |  Pubmed ID: 18236425

To report our experience with magnetic resonance imaging (MRI) in fetal heart evaluation.

Diffusion-weighted MR Imaging and Apparent Diffusion Coefficient of the Normal Fetal Lung: Preliminary Experience

Prenatal Diagnosis. Aug, 2008  |  Pubmed ID: 18567059

To assess if a correlation is present between apparent diffusion coefficient (ADC) values and normal lung maturation during gestation to define potential reference values as indicators of the lung development.

Breast MRI: Are T2 IR Sequences Useful in the Evaluation of Breast Lesions?

European Journal of Radiology. Jul, 2009  |  Pubmed ID: 18479866

To evaluate the potential role of signal intensities calculated in T2 images as an adjunctive parameter in the analysis of mass-like enhancements classified as BIRADS (Breast Imaging Reporting and Data System) assessment categories 2, 3, 4 or 5 with the standard T1 criteria.

Practical Application of Contrast-enhanced Magnetic Resonance Mammography [CE-MRM] by an Algorithm Combining Morphological and Enhancement Patterns

Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society. Mar, 2009  |  Pubmed ID: 19095407

The purpose of this article is to report our practical utilization of dynamic contrast-enhanced magnetic resonance mammography [DCE-MRM] in the diagnosis of breast lesions. In many European centers, was preferred a high-temporal acquisition of both breasts simultaneously in a large FOV. We preferred to scan single breasts, with the aim to combine the analysis of the contrast intake and washout with the morphological evaluation of breast lesions. We followed an interpretation model, based upon a diagnostic algorithm, which combined contrast enhancement with morphological evaluation, in order to increase our confidence in diagnosis. DCE-MRM with our diagnostic algorithm has identified 179 malignant and 41 benign lesions; final outcome has identified 178 malignant and 42 benign lesions, 3 false positives and 2 false negatives. Sensitivity of CE-MRM was 98.3%; specificity, 95.1%; positive predictive value, 98.9%; negative predictive value, 92.8% and accuracy, 97.7%.

Carotid Body Tumors: Radioguided Surgical Approach

Journal of Experimental & Clinical Cancer Research : CR. Dec, 2009  |  Pubmed ID: 20003252

Carotid body tumours (CBTs) are very rare lesions which should be treated as soon as possible even when benign since small tumour size permits easier removal and lower incidence of perioperative complications and recurrence. Malignant forms are rare and they can be identified by lymph node invasion and metastases in distant locations. The need of reliable and effective diagnostic modalities for both primary CBTs and its metastases or recurrence is evident.The present study reviews our experience and attempt to define the role of colour coded ultrasound (CCU) and Somatostatin receptor scintigraphy (SRS) with Indium-111-DTPA-pentetretide (Octreoscan(R)) using both planar and single photon emission tomography (SPECT) technique in the diagnosis and follow-up of these uncommon lesions within a multidisciplinary approach.

Fetal Abdominal Lymphangioma Enhanced by Ultrafast MRI

Fetal Diagnosis and Therapy. 2010  |  Pubmed ID: 19940451

Abdominal lymphangioma represents an uncommon congenital anomaly. Herein, we describe an unusual case, which on routine antenatal ultrasonography masqueraded as isolated ascites. Subsequent fetal MRI at 27 weeks' gestation implemented antenatal assessment of the lesion, prompting further investigations and straightforward postnatal treatment. Fetal MRI represents a valuable adjunct to antenatal ultrasonography for the evaluation of cystic abdominal masses.

Early Predictors of Juvenile Sacroiliitis in Enthesitis-related Arthritis

The Journal of Rheumatology. Nov, 2010  |  Pubmed ID: 20810515

To identify early predictors of sacroiliac (SI) involvement in a cohort of patients with enthesitis-related arthritis (ERA).

MRI and DWI: Feasibility of DWI and ADC Maps in the Evaluation of Placental Changes During Gestation

Prenatal Diagnosis. Dec, 2010  |  Pubmed ID: 21064115

To establish if a correlation exists between apparent diffusion coefficient (ADC) values, obtained by diffusion-weighted imaging (DWI), and placental aging.

Primary Osteosarcoma of the Breast

The Breast Journal. Nov-Dec, 2010  |  Pubmed ID: 21070446

A Well-documented Multimodality Imaging Approach to Fetus in Fetu: Pre- and Postnatal Imaging Features

Pediatric Radiology. Oct, 2011  |  Pubmed ID: 21681617

Exploring PTX3 Expression in Sus Scrofa Cardiac Tissue Using RNA Sequencing

Regulatory Peptides. Feb, 2012  |  Pubmed ID: 22120828

The prototypic long pentraxin PTX3 is a novel vascular inflammatory marker sharing similarities with the classic short pentraxin (C-reactive protein). PTX3 is rapidly produced and released by several cell types in response to local inflammation of the cardiovascular system. Plasma PTX3 levels are very low in normal conditions and increase in heart failure (HF) patients with advancing NYHA functional class, but its exact role during HF pathogenetic mechanisms is not yet established. No data about PTX3 cardiac expression in normal and pathological conditions are currently available, either in human or in large-size animals. Of the latter, the pig has a central role in "in vivo" clinical settings but its genome has not been completely sequenced and the PTX3 gene sequence is still lacking. The aim of this study was to sequence the PTX3 in Sus scrofa, whose sequence is not yet present in GenBank. Utilizing our knowledge of this sequence, PTX3 mRNA expression was evaluated in cardiac tissue of normal (n=6) and HF pigs (n=5), obtained from the four chambers. To sequence PTX3 gene in S. scrofa, the high homology between Homo sapiens and S. scrofa was exploited. Pig PTX3 mRNA was sequenced using polymerase chain reaction primers designed from human consensus sequences. The DNA, obtained from different RT-PCR reactions, was sequenced using the Sanger method. S. scrofa PTX3 mRNA, 1-336 bp, was submitted to GenBank (ID: GQ412351). The sequence obtained from pig cardiac tissue shared an 84% sequence identity with human homolog. The presence of PTX3 mRNA expression was detected in all the cardiac chambers sharing an increase after 3 weeks of pacing compared to controls (p=0.036 HF right atrium vs. N; p=0.022, HF left ventricle vs. N). Knowledge of the PTX3 sequence could be a useful starting point for future studies devoted to better understanding the specific role of this molecule in the pathogenesis of cardiovascular diseases.

Utility of Magnetic Resonance Imaging when Following Up Sacroiliitis in Enthesitis-related Arthritis

Modern Rheumatology. Nov, 2012  |  Pubmed ID: 22310966

Chest Fast MRI: an Imaging Alternative on Pre-operative Evaluation of Pectus Excavatum

Journal of Pediatric Surgery. Mar, 2012  |  Pubmed ID: 22424342

Standard imaging methods in evaluating chest wall deformities, such as Pectus Excavatum (PE) in paediatric and adolescent patients, include baseline 2-view chest radiography and chest CT scan. Only few studies to date investigated the value of fast MRIin the pre operative assessment of patient affected by PE.

Acute Encephalopathy in the Immune-compromised Child: Never Forget Toxoplasmosis

Journal of Pediatric Hematology/oncology. Jul, 2012  |  Pubmed ID: 22627571

Toxoplasma gondii is an opportunistic parasite, which very unusually may cause acute encephalitis in patients undergoing chemotherapy or hematopoietic stem cell transplant. The prognosis is usually dismal also because of late diagnosis, depending on the limited availability of specific diagnostic tools. An early diagnosis allows effective intervention with specific antibiotics, which may provide a chance for cure. We report 2 cases of cerebral toxoplasmosis in which the use of polymerase chain reaction on cerebrospinal fluid allowed a prompt diagnosis and specific therapy, which was followed by clinical response and negativization at follow-up studies of T. gondii genome on cerebrospinal fluid by polymerase chain reaction and by brain imaging.

Safety and Efficacy of Topiramate in Neonates with Hypoxic Ischemic Encephalopathy Treated with Hypothermia (NeoNATI)

BMC Pediatrics. Sep, 2012  |  Pubmed ID: 22950861

Despite progresses in neonatal care, the mortality and the incidence of neuro-motor disability after perinatal asphyxia have failed to show substantial improvements. In countries with a high level of perinatal care, the incidence of asphyxia responsible for moderate or severe encephalopathy is still 2-3 per 1000 term newborns. Recent trials have demonstrated that moderate hypothermia, started within 6 hours after birth and protracted for 72 hours, can significantly improve survival and reduce neurologic impairment in neonates with hypoxic-ischemic encephalopathy. It is not currently known whether neuroprotective drugs can further improve the beneficial effects of hypothermia. Topiramate has been proven to reduce brain injury in animal models of neonatal hypoxic ischemic encephalopathy. However, the association of mild hypothermia and topiramate treatment has never been studied in human newborns. The objective of this research project is to evaluate, through a multicenter randomized controlled trial, whether the efficacy of moderate hypothermia can be increased by concomitant topiramate treatment.

Adenovirus Pneumonia During Induction Therapy for Childhood Acute Lymphoblastic Leukemia

Pediatric Blood & Cancer. Aug, 2013  |  Pubmed ID: 23630183

Knowledge About Umbilical Cord Blood Donation: a Survey-based Study Performed in Tuscany

Blood Transfusion = Trasfusione Del Sangue. Oct, 2015  |  Pubmed ID: 25761314

Early Diagnosis and Monitoring of Neurodegenerative Langerhans Cell Histiocytosis

PloS One. 2015  |  Pubmed ID: 26176859

Neurodegenerative Langerhans Cell Histiocytosis (ND-LCH) is a rare, unpredictable consequence that may devastate the quality of life of patients cured from LCH. We prospectively applied a multidisciplinary diagnostic work-up to early identify and follow-up patients with ND-LCH, with the ultimate goal of better determining the appropriate time for starting therapy.

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