Sergei Sukharev

Publications

• Activation of Bacterial Channel MscL in Mechanically Stimulated Droplet Interface Bilayers
  Scientific Reports. 2015  |   Pubmed ID: 26348441
• Effects of Lys to Glu Mutations in GsMTx4 on Membrane Binding, Peptide Orientation, and Self-association Propensity, As Analyzed by Molecular Dynamics Simulations
  Biochimica Et Biophysica Acta. Nov, 2015  |   Pubmed ID: 26342676
• Membrane Affinity of Platensimycin and Its Dialkylamine Analogs
  International Journal of Molecular Sciences. 2015  |   Pubmed ID: 26247942
• Catalytic Role of the Substrate Defines Specificity of Therapeutic L-Asparaginase
  Journal of Molecular Biology. Aug, 2015  |   Pubmed ID: 26142822
• Properties of Diphytanoyl Phospholipids at the Air-water Interface
  Langmuir : the ACS Journal of Surfaces and Colloids. Jan, 2015  |   Pubmed ID: 25474305
• The Cytoplasmic Cage Domain of the Mechanosensitive Channel MscS is a Sensor of Macromolecular Crowding
  The Journal of General Physiology. May, 2014  |   Pubmed ID: 24778428
• The Glutaminase Activity of L-asparaginase is Not Required for Anticancer Activity Against ASNS-negative Cells
  Blood. Jun, 2014  |   Pubmed ID: 24659632
• The Mechanoelectrical Response of the Cytoplasmic Membrane of Vibrio Cholerae
  The Journal of General Physiology. Jul, 2013  |   Pubmed ID: 23797422
• Molecular Force Transduction by Ion Channels: Diversity and Unifying Principles
  Journal of Cell Science. Jul, 2012  |   Pubmed ID: 22797911
• Effects on Membrane Lateral Pressure Suggest Permeation Mechanisms for Bacterial Quorum Signaling Molecules
  Biochemistry. Aug, 2011  |   Pubmed ID: 21736305
• The Pathway and Spatial Scale for MscS Inactivation
  The Journal of General Physiology. Jul, 2011  |   Pubmed ID: 21670207
• Adaptive MscS Gating in the Osmotic Permeability Response in E. Coli: the Question of Time
  Biochemistry. May, 2011  |   Pubmed ID: 21456519
• Structural Models of TREK Channels and Their Gating Mechanism
  Channels (Austin, Tex.). Jan-Feb, 2011  |   Pubmed ID: 21084863
• Analyses of Gating Thermodynamics and Effects of Deletions in the Mechanosensitive Channel TREK-1: Comparisons with Structural Models
  Channels (Austin, Tex.). Jan-Feb, 2011  |   Pubmed ID: 21057213
• Effects of GsMTx4 on Bacterial Mechanosensitive Channels in Inside-out Patches from Giant Spheroplasts
  Biophysical Journal. Nov, 2010  |   Pubmed ID: 21044584
• Mechanosensitive Channels in Microbes
  Annual Review of Microbiology. 2010  |   Pubmed ID: 20825352
• Adaptive Behavior of Bacterial Mechanosensitive Channels is Coupled to Membrane Mechanics
  The Journal of General Physiology. Jun, 2010  |   Pubmed ID: 20513760
• Gadolinium Ions Block Mechanosensitive Channels by Altering the Packing and Lateral Pressure of Anionic Lipids
  Biophysical Journal. Mar, 2010  |   Pubmed ID: 20303859
• The Tension-transmitting 'clutch' in the Mechanosensitive Channel MscS
  Nature Structural & Molecular Biology. Apr, 2010  |   Pubmed ID: 20208543
• State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation
  The Journal of Biological Chemistry. Jul, 2009  |   Pubmed ID: 19383606
• The Membrane Lateral Pressure-perturbing Capacity of Parabens and Their Effects on the Mechanosensitive Channel Directly Correlate with Hydrophobicity
  Biochemistry. Oct, 2008  |   Pubmed ID: 18795793
• Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance
  The Journal of General Physiology. Jul, 2008  |   Pubmed ID: 18591417
• Characterization of the Resting MscS: Modeling and Analysis of the Closed Bacterial Mechanosensitive Channel of Small Conductance
  Biophysical Journal. Feb, 2008  |   Pubmed ID: 17981908
• Straightening and Sequential Buckling of the Pore-lining Helices Define the Gating Cycle of MscS
  Nature Structural & Molecular Biology. Dec, 2007  |   Pubmed ID: 18037888
• 2,2,2-Trifluoroethanol Changes the Transition Kinetics and Subunit Interactions in the Small Bacterial Mechanosensitive Channel MscS
  Biophysical Journal. Apr, 2007  |   Pubmed ID: 17277184
• Capping Transmembrane Helices of MscL with Aromatic Residues Changes Channel Response to Membrane Stretch
  Biochemistry. Sep, 2005  |   Pubmed ID: 16156671
• Explicit Channel Conductance: Can It Be Computed?
  Biophysical Journal. Jun, 2005  |   Pubmed ID: 15764668
• Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL
  The Journal of General Physiology. Feb, 2005  |   Pubmed ID: 15684093
• The "dashpot" Mechanism of Stretch-dependent Gating in MscS
  The Journal of General Physiology. Feb, 2005  |   Pubmed ID: 15657299
• Mechanosensitive Channels: What Can We Learn from 'simple' Model Systems?
  Trends in Neurosciences. Jun, 2004  |   Pubmed ID: 15165739
• Water Dynamics and Dewetting Transitions in the Small Mechanosensitive Channel MscS
  Biophysical Journal. May, 2004  |   Pubmed ID: 15111405
• Gating of the Large Mechanosensitive Channel in Situ: Estimation of the Spatial Scale of the Transition from Channel Population Responses
  Biophysical Journal. May, 2004  |   Pubmed ID: 15111402
• Mechanosensitive Channels: Multiplicity of Families and Gating Paradigms
  Science's STKE : Signal Transduction Knowledge Environment. Feb, 2004  |   Pubmed ID: 14872099
• On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL
  The Journal of General Physiology. Mar, 2003  |   Pubmed ID: 12601086
• A Large Iris-like Expansion of a Mechanosensitive Channel Protein Induced by Membrane Tension
  Nature Structural Biology. Sep, 2002  |   Pubmed ID: 12172538
• Purification of the Small Mechanosensitive Channel of Escherichia Coli (MscS): the Subunit Structure, Conduction, and Gating Characteristics in Liposomes
  Biophysical Journal. Jul, 2002  |   Pubmed ID: 12080120