In JoVE (1)
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Articles by Siddharth Chatterji in JoVE
Stiffness Measurement of Soft Silicone Substrates for Mechanobiology Studies Using a Widefield Fluorescence Microscope Yashar Bashirzadeh*1, Siddharth Chatterji*1, Dakota Palmer*2, Sandeep Dumbali*1, Shizhi Qian1, Venkat Maruthamuthu1 1Department of Mechanical & Aerospace Engineering, Old Dominion University, 2Department of Biological Sciences, Old Dominion University Substrates with stiffness in the kilopascal-range are useful to study the response of cells to physiologically relevant micro-environment stiffness. Using just a widefield fluorescence microscope, the Young's modulus of soft silicone gels can be determined using an indentation with a suitable sphere.