Sidney W. Whiteheart Department of Molecular and Cellular Biochemistry University of Kentucky Biography Publications Institution JoVE Articles Sidney W. Whiteheart has not added a biography. If you are Sidney W. Whiteheart and would like to personalize this page please email our Author Liaison for assistance. Publications In Memory of Dr. Susan S. Smyth, MD/Ph.D Platelets. Dec, 2023 | Pubmed ID: 36813743 A Sensitive and Adaptable Method to Measure Platelet-fibrin Clot Contraction Kinetics Research and Practice in Thrombosis and Haemostasis. Jul, 2022 | Pubmed ID: 35873218 Total Plasma Protein S Is a Prothrombotic Marker in People Living With HIV Journal of Acquired Immune Deficiency Syndromes (1999). Aug, 2022 | Pubmed ID: 35616596 COMManding Platelet α-granule Cargo Blood. Feb, 2022 | Pubmed ID: 35142851 VAMP3 and VAMP8 Regulate the Development and Functionality of Parasitophorous Vacuoles Housing Leishmania Amazonensis Infection and Immunity. Mar, 2022 | Pubmed ID: 35130453 Platelet-HIV: Interactions and Their Implications Platelets. Feb, 2022 | Pubmed ID: 35086429 Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) Via Its Ability to Interact with NSF Directly? Handbook of Experimental Pharmacology. 2022 | Pubmed ID: 33404775 Differential Leukocyte and Platelet Profiles in Distinct Models of Traumatic Brain Injury Cells. Feb, 2021 | Pubmed ID: 33652745 Platelet α-granule Cargo Packaging and Release Are Affected by the Luminal Proteoglycan, Serglycin Journal of Thrombosis and Haemostasis : JTH. Apr, 2021 | Pubmed ID: 33448622 Calcium Ion Chelation Preserves Platelet Function During Cold Storage Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2021 | Pubmed ID: 33176450 Structural Analysis of Resting Mouse Platelets by 3D-EM Reveals an Unexpected Variation in α-granule Shape Platelets. Jul, 2021 | Pubmed ID: 32815431 Canalicular System Reorganization During Mouse Platelet Activation As Revealed by 3D Ultrastructural Analysis Platelets. Jan, 2021 | Pubmed ID: 32000578 Hemostasis Vs. Homeostasis: Platelets Are Essential for Preserving Vascular Barrier Function in the Absence of Injury or Inflammation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2020 | Pubmed ID: 32929010 Platelets Endocytose Viral Particles and Are Activated Via TLR (Toll-Like Receptor) Signaling Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2020 | Pubmed ID: 32434410 Modulation of Epileptogenesis: A Paradigm for the Integration of Enzyme-based Microelectrode Arrays and Optogenetics Epilepsy Research. Jan, 2020 | Pubmed ID: 31816591 Autophagy in Platelets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30610718 In Vivo Modeling of Docosahexaenoic Acid and Eicosapentaenoic Acid-mediated Inhibition of Both Platelet Function and Accumulation in Arterial Thrombi Platelets. 2019 | Pubmed ID: 29286871 SNARE-dependent Membrane Fusion Initiates α-granule Matrix Decondensation in Mouse Platelets Blood Advances. Nov, 2018 | Pubmed ID: 30401752 Alterations in Platelet Secretion Differentially Affect Thrombosis and Hemostasis Blood Advances. Sep, 2018 | Pubmed ID: 30185436 BEACHcombing for α-granules Blood. Mar, 2018 | Pubmed ID: 29496701 Dynamic Cycling of T-SNARE Acylation Regulates Platelet Exocytosis The Journal of Biological Chemistry. 03, 2018 | Pubmed ID: 29352103 Linking Kindling to Increased Glutamate Release in the Dentate Gyrus of the Hippocampus Through the STXBP5/tomosyn-1 Gene Brain and Behavior. Sep, 2017 | Pubmed ID: 28948088 Cellubrevin/vesicle-associated Membrane Protein-3-mediated Endocytosis and Trafficking Regulate Platelet Functions Blood. Dec, 2017 | Pubmed ID: 28931526 Fueling Platelets: Where Does the Glucose Come From? Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2017 | Pubmed ID: 28835484 The Ins and Outs of Endocytic Trafficking in Platelet Functions Current Opinion in Hematology. Sep, 2017 | Pubmed ID: 28650849 Editorial: Platelet Secretion Platelets. Mar, 2017 | Pubmed ID: 28281920 The Nuts and Bolts of the Platelet Release Reaction Platelets. Mar, 2017 | Pubmed ID: 27848265 Respective Contributions of Single and Compound Granule Fusion to Secretion by Activated Platelets Blood. 11, 2016 | Pubmed ID: 27625359 B-cell-independent Sialylation of IgG Proceedings of the National Academy of Sciences of the United States of America. Jun, 2016 | Pubmed ID: 27303031 How Does Protein Disulfide Isomerase Get Into a Thrombus? Arteriosclerosis, Thrombosis, and Vascular Biology. 06, 2016 | Pubmed ID: 27225788 Arf6 Controls Platelet Spreading and Clot Retraction Via Integrin αIIbβ3 Trafficking Blood. Mar, 2016 | Pubmed ID: 26738539 Role of Munc13-4 As a Ca2+-dependent Tether During Platelet Secretion The Biochemical Journal. Mar, 2016 | Pubmed ID: 26637270 Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis Circulation. Dec, 2015 | Pubmed ID: 26399659 Autophagy is Induced Upon Platelet Activation and is Essential for Hemostasis and Thrombosis Blood. Sep, 2015 | Pubmed ID: 26209658 Platelet Secretion Paves the Way Blood. Jul, 2015 | Pubmed ID: 26206945 Platelet Secretion and Hemostasis Require Syntaxin-binding Protein STXBP5 The Journal of Clinical Investigation. Oct, 2014 | Pubmed ID: 25244094 Granule-mediated Release of Sphingosine-1-phosphate by Activated Platelets Biochimica Et Biophysica Acta. Nov, 2014 | Pubmed ID: 25158625 TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-presentation Cell. Jul, 2014 | Pubmed ID: 25083866 α-Granules at the BEACH Blood. Nov, 2013 | Pubmed ID: 24203928 Platelets Protect from Septic Shock by Inhibiting Macrophage-dependent Inflammation Via the Cyclooxygenase 1 Signalling Pathway Nature Communications. 2013 | Pubmed ID: 24150174 IκB Kinase Phosphorylation of SNAP-23 Controls Platelet Secretion Blood. May, 2013 | Pubmed ID: 23613522 Platelet Secretion is Kinetically Heterogeneous in an Agonist-responsive Manner Blood. Dec, 2012 | Pubmed ID: 23086755 The Src Family Kinases and Protein Kinase C Synergize to Mediate Gq-dependent Platelet Activation The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23066026 Munc18b/STXBP2 is Required for Platelet Secretion Blood. Sep, 2012 | Pubmed ID: 22791290 Syntaxin-11, but Not Syntaxin-2 or Syntaxin-4, is Required for Platelet Secretion Blood. Sep, 2012 | Pubmed ID: 22767500 Nucleotide-dependent Conformational Changes in the N-Ethylmaleimide Sensitive Factor (NSF) and Their Potential Role in SNARE Complex Disassembly Journal of Structural Biology. Feb, 2012 | Pubmed ID: 22245547 Reduction of Vesicle-associated Membrane Protein 2 Expression Leads to a Kindling-resistant Phenotype in a Murine Model of Epilepsy Neuroscience. Jan, 2012 | Pubmed ID: 22183055 Kindling-induced Asymmetric Accumulation of Hippocampal 7S SNARE Complexes Correlates with Enhanced Glutamate Release Epilepsia. Jan, 2012 | Pubmed ID: 22150629 Requirements for the Catalytic Cycle of the N-ethylmaleimide-Sensitive Factor (NSF) Biochimica Et Biophysica Acta. Jan, 2012 | Pubmed ID: 21689688 Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3 Outside-in Signaling The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21940635 Platelet Granules: Surprise Packages Blood. Aug, 2011 | Pubmed ID: 21816838 A Novel Role for Platelet Secretion in Angiogenesis: Mediating Bone Marrow-derived Cell Mobilization and Homing Blood. Apr, 2011 | Pubmed ID: 21224474 Histidine-tag-directed Chromophores for Tracer Analyses in the Analytical Ultracentrifuge Methods (San Diego, Calif.). May, 2011 | Pubmed ID: 21187151 Munc13-4 is a Limiting Factor in the Pathway Required for Platelet Granule Release and Hemostasis Blood. Aug, 2010 | Pubmed ID: 20435885 Protein Expression in Platelets from Six Species That Differ in Their Open Canalicular System Platelets. 2010 | Pubmed ID: 20196629 Hexahistidine-tag-specific Optical Probes for Analyses of Proteins and Their Interactions Analytical Biochemistry. Apr, 2010 | Pubmed ID: 20036207 Dissecting the N-ethylmaleimide-sensitive Factor: Required Elements of the N and D1 Domains The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19887446 Endobrevin/VAMP-8-dependent Dense Granule Release Mediates Thrombus Formation in Vivo Blood. Jul, 2009 | Pubmed ID: 19395672 PKCalpha Regulates Platelet Granule Secretion and Thrombus Formation in Mice The Journal of Clinical Investigation. Feb, 2009 | Pubmed ID: 19147982 The Platelet Release Reaction: Just when You Thought Platelet Secretion Was Simple Current Opinion in Hematology. Sep, 2008 | Pubmed ID: 18695380 Levetiracetam Prevents Kindling-induced Asymmetric Accumulation of Hippocampal 7S SNARE Complexes Epilepsia. Oct, 2008 | Pubmed ID: 18513349 Murine Platelets Are Not Regulated by O-linked Beta-N-acetylglucosamine Archives of Biochemistry and Biophysics. Jun, 2008 | Pubmed ID: 18387355 Primary Platelet Signaling Cascades and Integrin-mediated Signaling Control ADP-ribosylation Factor (Arf) 6-GTP Levels During Platelet Activation and Aggregation The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18326492 Platelet Activation and Its Patient-specific Consequences Thrombosis Research. 2008 | Pubmed ID: 17949794 Cellular Functions of NSF: Not Just SNAPs and SNAREs FEBS Letters. May, 2007 | Pubmed ID: 17397838 Asymmetric Accumulation of Hippocampal 7S SNARE Complexes Occurs Regardless of Kindling Paradigm Epilepsy Research. Mar, 2007 | Pubmed ID: 17174072 Endobrevin/VAMP-8 is the Primary V-SNARE for the Platelet Release Reaction Molecular Biology of the Cell. Jan, 2007 | Pubmed ID: 17065550 Arf6 Plays an Early Role in Platelet Activation by Collagen and Convulxin Blood. Apr, 2006 | Pubmed ID: 16352809 Platelets from Munc18c Heterozygous Mice Exhibit Normal Stimulus-induced Release Thrombosis and Haemostasis. Oct, 2004 | Pubmed ID: 15467915 Studies of Secretion Using Permeabilized Platelets Methods in Molecular Biology (Clifton, N.J.). 2004 | Pubmed ID: 15226539 Multiple Binding Proteins Suggest Diverse Functions for the N-ethylmaleimide Sensitive Factor Journal of Structural Biology. 2004 | Pubmed ID: 15037235 A Role for Sec1/Munc18 Proteins in Platelet Exocytosis The Biochemical Journal. Aug, 2003 | Pubmed ID: 12773094 Granule Stores from Cellubrevin/VAMP-3 Null Mouse Platelets Exhibit Normal Stimulus-induced Release Blood. Sep, 2003 | Pubmed ID: 12738662 Application of a Saccharomyces Cerevisiae Model to Study Requirements for Trafficking of Yersinia Pestis YopM in Eucaryotic Cells Infection and Immunity. Feb, 2003 | Pubmed ID: 12540576 Uncoupling the ATPase Activity of the N-ethylmaleimide Sensitive Factor (NSF) from 20S Complex Disassembly Biochemistry. Jan, 2002 | Pubmed ID: 11781091 The SNARE Machinery is Involved in Apical Plasma Membrane Trafficking in MDCK Cells The Journal of Cell Biology. Jun, 1998 | Pubmed ID: 9647644 פקקת עורקים המושרה על ידי ברזל כלוריד ואיסוף דגימות לניתוח מיקרוסקופ אלקטרונים תלת ממדי Smita Joshi*1, Alexis N. Smith1, Kanakanagavalli Shravani Prakhya1, Hammodah R. Alfar1, Joshua Lykins1, Ming Zhang1, Irina Pokrovskaya2, Maria Aronova3, Richard D. Leapman3, Brian Storrie2, Sidney W. Whiteheart*1 1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, 3Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health JoVE 64985 Medicine חיסונים של האלפקות (לאמה pacos) עם חלבונים אנטיגניים וייצור נוגדנים תחום יחיד אנטיגן ספציפי K. Martin Chow1, Sidney W. Whiteheart1, Jeffrey R. Smiley2, Savita Sharma1, Kathy Boaz2, Meggie J. Coleman2, Alvina Maynard3, Louis B. Hersh1, Craig W. Vander Kooi1 1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Division of Laboratory Animal Resources, University of Kentucky, 3River Hill Ranch JoVE 58471 Biochemistry
פקקת עורקים המושרה על ידי ברזל כלוריד ואיסוף דגימות לניתוח מיקרוסקופ אלקטרונים תלת ממדי Smita Joshi*1, Alexis N. Smith1, Kanakanagavalli Shravani Prakhya1, Hammodah R. Alfar1, Joshua Lykins1, Ming Zhang1, Irina Pokrovskaya2, Maria Aronova3, Richard D. Leapman3, Brian Storrie2, Sidney W. Whiteheart*1 1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, 3Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health JoVE 64985 Medicine
חיסונים של האלפקות (לאמה pacos) עם חלבונים אנטיגניים וייצור נוגדנים תחום יחיד אנטיגן ספציפי K. Martin Chow1, Sidney W. Whiteheart1, Jeffrey R. Smiley2, Savita Sharma1, Kathy Boaz2, Meggie J. Coleman2, Alvina Maynard3, Louis B. Hersh1, Craig W. Vander Kooi1 1Department of Molecular and Cellular Biochemistry, University of Kentucky, 2Division of Laboratory Animal Resources, University of Kentucky, 3River Hill Ranch JoVE 58471 Biochemistry
