Other Publications (1)
Articles by Thomas Andreska in JoVE
Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED) Samira Samtleben1, Juliane Jaepel1,2, Caroline Fecher1, Thomas Andreska1, Markus Rehberg3, Robert Blum1 1Institute for Clinical Neurobiology, University of Wuerzburg, 2Department of Synapses - Circuits - Plasticity, Max Planck Institute of Neurobiology, Martinsried, 3Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians University of Munich Targeted-esterase induced dye loading (TED) supports the analysis of intracellular calcium store dynamics by fluorescence imaging. The method bases on targeting of a recombinant Carboxylesterase to the endoplasmic reticulum (ER), where it improves the local unmasking of synthetic low-affinity Ca2+ indicator dyes in the ER lumen.
Other articles by Thomas Andreska on PubMed
From Stem Cells to Dopamine Neurons: Developmental Biology Meets Neurodegeneration CNS & Neurological Disorders Drug Targets. Nov, 2012 | Pubmed ID: 23131155 Neurodegenerative disease affects tens of millions of people, worldwide, and comes at a cost to the public of billions of dollars. Stem cell therapy, in recent years, has generated a lot of enthusiasm as a novel treatment for neurodegenerative disease. In particular, Parkinson's disease has been identified as the ideal neurodegenerative disease to be treated using stem cells. Despite years of setbacks, recent experimental results have renewed optimism in the validity of stem cell therapy for the treatment of Parkinson's disease. In this review, we discuss advances in our understanding of the embryonic development of the dopamine system and the importance of these discoveries in the continued efforts towards stem cell therapy for Parkinson's disease.