Ton Lisman Section of Hepato-Pancreato-Biliary Surgery and Liver Transplantation University of Groningen, University Medical Center Groningen Biography Publications Institution JoVE Articles Ton Lisman has not added a biography. If you are Ton Lisman and would like to personalize this page please email our Author Liaison for assistance. Publications Preserved Clot Formation Detected by the Thrombodynamics Analyzer in Patients with Cirrhosis Thrombosis Research. Feb, 2015 | Pubmed ID: 25746364 Development of a Hypercoagulable Status in Patients Undergoing Off-pump Lung Transplantation Despite Prolonged Conventional Coagulation Tests American Journal of Respiratory and Critical Care Medicine. Jan, 2015 | Pubmed ID: 25590158 Letter by Hugenholtz and Lisman Regarding Article, "plasmin Cleavage of Von Willebrand Factor As an Emergency Bypass for ADAMTS13 Deficiency in Thrombotic Microangiopathy" Circulation. Jan, 2015 | Pubmed ID: 25583060 Is There a Rationale for Treatment of Chronic Liver Disease with Antithrombotic Therapy? Blood Reviews. Mar, 2015 | Pubmed ID: 25468718 No Evidence for Increased Platelet Activation in Patients with Hepatitis B- or C-related Cirrhosis and Hepatocellular Carcinoma Thrombosis Research. Feb, 2015 | Pubmed ID: 25434630 Issues with Monitoring of Unfractionated Heparin in Cirrhosis Therapeutic Drug Monitoring. Apr, 2015 | Pubmed ID: 25265256 Decreased in Vitro Anticoagulant Potency of Rivaroxaban and Apixaban in Plasma from Patients with Cirrhosis Hepatology (Baltimore, Md.). Apr, 2015 | Pubmed ID: 25088782 Management of Coagulation Abnormalities in Liver Disease Expert Review of Gastroenterology & Hepatology. Jan, 2015 | Pubmed ID: 24970667 The Role of Cell Surfaces and Cellular Receptors in the Mode of Action of Recombinant Factor VIIa Blood Reviews. Dec, 2014 | Pubmed ID: 25553898 Evidence Against a Role of Serotonin in Liver Regeneration in Humans Hepatology (Baltimore, Md.). Dec, 2014 | Pubmed ID: 25546821 Infusion of DDAVP Does Not Improve Primary Hemostasis in Patients with Cirrhosis Liver International : Official Journal of the International Association for the Study of the Liver. Dec, 2014 | Pubmed ID: 25522671 Coagulation Activation During Air Travel is Not Initiated Via the Extrinsic Pathway British Journal of Haematology. Dec, 2014 | Pubmed ID: 25521220 Criteria for Viability Assessment of Discarded Human Donor Livers During Ex Vivo Normothermic Machine Perfusion PloS One. 2014 | Pubmed ID: 25369327 Abnormal Hemostatic Function One Year After Orthotopic Liver Transplantation Can Be Fully Attributed to Endothelial Cell Activation F1000Research. 2014 | Pubmed ID: 25285204 Levels of Angiogenic Proteins in Plasma and Platelets Are Not Different Between Patients with Hepatitis B/C-related Cirrhosis and Patients with Cirrhosis and Hepatocellular Carcinoma Platelets. Oct, 2014 | Pubmed ID: 25275728 Low Molecular Weight Heparin in Management and Prevention of Portal Vein Thrombosis Thrombosis Research. Oct, 2014 | Pubmed ID: 25179517 Early Elevated Serum Gamma Glutamyl Transpeptidase After Liver Transplantation is Associated with Better Survival F1000Research. 2014 | Pubmed ID: 25075298 Thrombomodulin-modified Thrombin Generation Testing Detects a Hypercoagulable State in Patients with Cirrhosis Regardless of the Exact Experimental Conditions Thrombosis Research. Sep, 2014 | Pubmed ID: 25065556 Hemostasis in Liver Disease: Implications of New Concepts for Perioperative Management Transfusion Medicine Reviews. Jul, 2014 | Pubmed ID: 24721432 Injury to Peribiliary Glands and Vascular Plexus Before Liver Transplantation Predicts Formation of Non-anastomotic Biliary Strictures Journal of Hepatology. Jun, 2014 | Pubmed ID: 24560661 Hypothermic Oxygenated Machine Perfusion Prevents Arteriolonecrosis of the Peribiliary Plexus in Pig Livers Donated After Circulatory Death PloS One. 2014 | Pubmed ID: 24551114 Differential in Vitro Inhibition of Thrombin Generation by Anticoagulant Drugs in Plasma from Patients with Cirrhosis PloS One. 2014 | Pubmed ID: 24505487 Duct-to-duct Reconstruction in Liver Transplantation for Primary Sclerosing Cholangitis is Associated with Fewer Biliary Complications in Comparison with Hepaticojejunostomy Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Apr, 2014 | Pubmed ID: 24458730 Prophylactic Anticoagulation for Venous Thromboembolism in Hospitalized Cirrhosis Patients is Not Associated with High Rates of Gastrointestinal Bleeding Liver International : Official Journal of the International Association for the Study of the Liver. Jan, 2014 | Pubmed ID: 23758818 Routine Coagulation Assays Underestimate Levels of Antithrombin-dependent Drugs but Not of Direct Anticoagulant Drugs in Plasma from Patients with Cirrhosis British Journal of Haematology. Dec, 2013 | Pubmed ID: 24219333 Decreased Tissue Factor Pathway Inhibitor (TFPI)-dependent Anticoagulant Capacity in Patients with Cirrhosis Who Have Decreased Protein S but Normal TFPI Plasma Levels British Journal of Haematology. Sep, 2013 | Pubmed ID: 23841464 Prothrombin Complex Concentrate in the Reduction of Blood Loss During Orthotopic Liver Transplantation: PROTON-trial BMC Surgery. 2013 | Pubmed ID: 23815798 Established and New-generation Antithrombotic Drugs in Patients with Cirrhosis - Possibilities and Caveats Journal of Hepatology. Aug, 2013 | Pubmed ID: 23548197 Hypercoagulability As a Contributor to Thrombotic Complications in the Liver Transplant Recipient Liver International : Official Journal of the International Association for the Study of the Liver. Jul, 2013 | Pubmed ID: 23490221 An Unbalance Between Von Willebrand Factor and ADAMTS13 in Acute Liver Failure: Implications for Hemostasis and Clinical Outcome Hepatology (Baltimore, Md.). Aug, 2013 | Pubmed ID: 23468040 The Impact of Hepatic Steatosis on Liver Regeneration After Partial Hepatectomy Liver International : Official Journal of the International Association for the Study of the Liver. Mar, 2013 | Pubmed ID: 23311417 Eltrombopag Before Procedures in Patients with Cirrhosis and Thrombocytopenia The New England Journal of Medicine. Nov, 2012 | Pubmed ID: 23171114 Fibrinolytic Proteins in Human Bile Accelerate Lysis of Plasma Clots and Induce Breakdown of Fibrin Sealants Annals of Surgery. Aug, 2012 | Pubmed ID: 22797359 Beneficial Effects of Gaseous Hydrogen Sulfide in Hepatic Ischemia/reperfusion Injury Transplant International : Official Journal of the European Society for Organ Transplantation. Aug, 2012 | Pubmed ID: 22716165 Prohemostatic Interventions in Liver Surgery Seminars in Thrombosis and Hemostasis. Apr, 2012 | Pubmed ID: 22510858 Platelet Function in Stored Heparinised Autologous Blood is Not Superior to in Patient Platelet Function During Routine Cardiopulmonary Bypass PloS One. 2012 | Pubmed ID: 22442710 Role of Fibrin Sealants in Liver Surgery Digestive Surgery. 2012 | Pubmed ID: 22441621 Platelet Function in Patients with Cirrhosis Journal of Hepatology. Apr, 2012 | Pubmed ID: 22424439 Bivalirudin is Inferior to Heparin in Preservation of Intraoperative Autologous Blood Thrombosis Research. Aug, 2012 | Pubmed ID: 22261478 Pitfalls in Assessing Platelet Activation Status in Patients with Liver Disease Liver International : Official Journal of the International Association for the Study of the Liver. Jul, 2012 | Pubmed ID: 22212705 Regeneration of Human Extrahepatic Biliary Epithelium: the Peribiliary Glands As Progenitor Cell Compartment Liver International : Official Journal of the International Association for the Study of the Liver. Apr, 2012 | Pubmed ID: 22171992 Clot Lysis Time and the Risk of Myocardial Infarction and Ischaemic Stroke in Young Women; Results from the RATIO Case-control Study British Journal of Haematology. Jan, 2012 | Pubmed ID: 22082241 Minimal Effects of Acute Liver Injury/acute Liver Failure on Hemostasis As Assessed by Thromboelastography Journal of Hepatology. Jan, 2012 | Pubmed ID: 21703173 Recombinant Factor VIIa to Treat Severe Bleeding in Patients with Liver Disease: Pitfalls and Possibilities Journal of Hepatology. Oct, 2011 | Pubmed ID: 21925325 Prothrombotic Gene Polymorphisms: Possible Contributors to Hepatic Artery Thrombosis After Orthotopic Liver Transplantation Transplantation. Sep, 2011 | Pubmed ID: 21836539 Towards a Rational Use of Low-molecular-weight Heparin in Patients with Cirrhosis Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2011 | Pubmed ID: 21733099 Protection of Bile Ducts in Liver Transplantation: Looking Beyond Ischemia Transplantation. Aug, 2011 | Pubmed ID: 21629175 Proteolytic and Genetic Variation of the Alpha-2-antiplasmin C-terminus in Myocardial Infarction Blood. Jun, 2011 | Pubmed ID: 21505192 The Combination of Primary Sclerosing Cholangitis and CCR5-Δ32 in Recipients is Strongly Associated with the Development of Nonanastomotic Biliary Strictures After Liver Transplantation Liver International : Official Journal of the International Association for the Study of the Liver. Sep, 2011 | Pubmed ID: 21134114 The Hemostatic Status of Pediatric Recipients of Adult Liver Grafts Suggests That Plasma Levels of Hemostatic Proteins Are Not Regulated by the Liver Blood. Feb, 2011 | Pubmed ID: 21068434 Activation and Regulation of Hemostasis in Acute Liver Failure and Acute Pancreatitis Seminars in Thrombosis and Hemostasis. Jun, 2010 | Pubmed ID: 20614395 Hemostasis and Thrombosis in Patients with Liver Disease: the Ups and Downs Journal of Hepatology. Aug, 2010 | Pubmed ID: 20546962 The Role of Platelets in Liver Inflammation and Regeneration Seminars in Thrombosis and Hemostasis. Mar, 2010 | Pubmed ID: 20414832 Plasma Levels of Fibrinolytic Proteins and the Risk of Myocardial Infarction in Men Blood. Jul, 2010 | Pubmed ID: 20413657 Rebalanced Hemostasis in Patients with Liver Disease: Evidence and Clinical Consequences Blood. Aug, 2010 | Pubmed ID: 20400681 Reduced ADAMTS13 in Children with Severe Meningococcal Sepsis is Associated with Severity and Outcome Thrombosis and Haemostasis. Jun, 2010 | Pubmed ID: 20390223 Venous Thrombosis Risk Associated with Plasma Hypofibrinolysis is Explained by Elevated Plasma Levels of TAFI and PAI-1 Blood. Jul, 2010 | Pubmed ID: 20385790 The Interaction of Recombinant Factor VIIa with Platelet Glycoprotein Ib Thrombosis Research. Apr, 2010 | Pubmed ID: 20153024 Normal to Increased Thrombin Generation in Patients Undergoing Liver Transplantation Despite Prolonged Conventional Coagulation Tests Journal of Hepatology. Mar, 2010 | Pubmed ID: 20132999 Immediate Postoperative Low Platelet Count is Associated with Delayed Liver Function Recovery After Partial Liver Resection Annals of Surgery. Feb, 2010 | Pubmed ID: 19779326 Transmission of Idiopathic Thrombocytopenic Purpura During Orthotopic Liver Transplantation Transplant International : Official Journal of the European Society for Organ Transplantation. Feb, 2010 | Pubmed ID: 19691662 Should We Give Thromboprophylaxis to Patients with Liver Cirrhosis and Coagulopathy? HPB : the Official Journal of the International Hepato Pancreato Biliary Association. Sep, 2009 | Pubmed ID: 19816608 How to Minimize Blood Loss During Liver Surgery in Patients with Cirrhosis HPB : the Official Journal of the International Hepato Pancreato Biliary Association. Sep, 2009 | Pubmed ID: 19816607 Factor XI Binding to Platelets: Glycoprotein Ib Alpha Has an Accomplice Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2009 | Pubmed ID: 19759371 The Impact of the Fibrinolytic System on the Risk of Venous and Arterial Thrombosis Seminars in Thrombosis and Hemostasis. Jul, 2009 | Pubmed ID: 19739037 No Evidence for Systemic Platelet Activation During or After Orthotopic Liver Transplantation Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Aug, 2009 | Pubmed ID: 19642138 Inflammation Mediated Down-regulation of Hepatobiliary Transporters Contributes to Intrahepatic Cholestasis and Liver Damage in Murine Biliary Atresia Pediatric Research. Oct, 2009 | Pubmed ID: 19581828 Effects of Acidosis, Alkalosis, Hyperthermia and Hypothermia on Haemostasis: Results of Point-of-care Testing with the Thromboelastography Analyser Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis. Sep, 2009 | Pubmed ID: 19491662 Low Thrombin Activatable Fibrinolysis Inhibitor Activity Levels Are Associated with an Increased Risk of a First Myocardial Infarction in Men Haematologica. Jun, 2009 | Pubmed ID: 19377074 Platelet Transfusion During Liver Transplantation is Associated with Increased Postoperative Mortality Due to Acute Lung Injury Anesthesia and Analgesia. Apr, 2009 | Pubmed ID: 19299765 Assessment of Coagulation and Fibrinolysis in Families with Unexplained Thrombophilia Thrombosis and Haemostasis. Mar, 2009 | Pubmed ID: 19277406 Hypofibrinolysis is a Risk Factor for Arterial Thrombosis at Young Age British Journal of Haematology. Apr, 2009 | Pubmed ID: 19183334 Reduced Plasma Fibrinolytic Capacity As a Potential Risk Factor for a First Myocardial Infarction in Young Men British Journal of Haematology. Apr, 2009 | Pubmed ID: 19170679 Bleeding in Liver Surgery: Prevention and Treatment Clinics in Liver Disease. Feb, 2009 | Pubmed ID: 19150318 The Platelet and Platelet Function Testing in Liver Disease Clinics in Liver Disease. Feb, 2009 | Pubmed ID: 19150305 Hepatic Artery Thrombosis After Liver Transplantation: More Than Just a Surgical Complication? Transplant International : Official Journal of the European Society for Organ Transplantation. Feb, 2009 | Pubmed ID: 18796001 The Two Tales of Coagulation in Liver Transplantation Current Opinion in Organ Transplantation. Jun, 2008 | Pubmed ID: 18685321 Salvianolic Acid B Inhibits Platelet Adhesion Under Conditions of Flow by a Mechanism Involving the Collagen Receptor Alpha2beta1 Thrombosis Research. 2008 | Pubmed ID: 18625517 The Glycoprotein Ib-IX-V Complex Contributes to Tissue Factor-independent Thrombin Generation by Recombinant Factor VIIa on the Activated Platelet Surface Blood. Oct, 2008 | Pubmed ID: 18612104 Platelets in Liver Transplantation: Friend or Foe? Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Jul, 2008 | Pubmed ID: 18581510 Tissue Factor-independent Effects of Recombinant Factor VIIa on Hemostasis Seminars in Hematology. Apr, 2008 | Pubmed ID: 18544417 Interlaboratory Variability in Assessment of the Model of End-stage Liver Disease Score Liver International : Official Journal of the International Association for the Study of the Liver. Dec, 2008 | Pubmed ID: 18482269 Synergistic Effects of Hypofibrinolysis and Genetic and Acquired Risk Factors on the Risk of a First Venous Thrombosis PLoS Medicine. May, 2008 | Pubmed ID: 18462012 Cell-collagen Interactions: the Use of Peptide Toolkits to Investigate Collagen-receptor Interactions Biochemical Society Transactions. Apr, 2008 | Pubmed ID: 18363567 Prospective Evaluation of Coagulopathy in Multiple Myeloma Patients Before, During and After Various Chemotherapeutic Regimens Leukemia Research. Jul, 2008 | Pubmed ID: 18241919 A Heparin-bonded Vascular Graft Generates No Systemic Effect on Markers of Hemostasis Activation or Detectable Heparin-induced Thrombocytopenia-associated Antibodies in Humans Journal of Vascular Surgery. Feb, 2008 | Pubmed ID: 18241756 The Influence of the Pulsatility of the Blood Flow on the Extent of Platelet Adhesion Thrombosis Research. 2008 | Pubmed ID: 17884149 Platelet Activation by Oxidized Low Density Lipoprotein is Mediated by CD36 and Scavenger Receptor-A Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2007 | Pubmed ID: 17761940 Hemostatic Alterations in Liver Disease: a Review on Pathophysiology, Clinical Consequences, and Treatment Digestive Surgery. 2007 | Pubmed ID: 17657149 Antiplatelet Medication After Liver Transplantation: Does It Affect Outcome? Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. May, 2007 | Pubmed ID: 17457859 Fibrinolysis and the Risk of Venous and Arterial Thrombosis Current Opinion in Hematology. May, 2007 | Pubmed ID: 17414214 Variations in Glycosylation of Von Willebrand Factor with O-linked Sialylated T Antigen Are Associated with Its Plasma Levels Blood. Mar, 2007 | Pubmed ID: 17090649 Coagulation Disorders and Hemostasis in Liver Disease: Pathophysiology and Critical Assessment of Current Management Hepatology (Baltimore, Md.). Oct, 2006 | Pubmed ID: 17006940 Severe Prolongation of the INR in Spur Cell Anemia of Cirrhosis: True-true and Related? Digestive Diseases and Sciences. Jul, 2006 | Pubmed ID: 16944010 A Single High-affinity Binding Site for Von Willebrand Factor in Collagen III, Identified Using Synthetic Triple-helical Peptides Blood. Dec, 2006 | Pubmed ID: 16912226 Análisis De Los Factores Trombóticos En El Síndrome Respiratorio Agudo Severo (SRAS), Los Pacientes Thrombosis and Haemostasis. Jul, 2006 | Pubmed ID: 16807662 Elevated Levels of Von Willebrand Factor in Cirrhosis Support Platelet Adhesion Despite Reduced Functional Capacity Hepatology (Baltimore, Md.). Jul, 2006 | Pubmed ID: 16799972 Collagens Are Functional, High Affinity Ligands for the Inhibitory Immune Receptor LAIR-1 The Journal of Experimental Medicine. Jun, 2006 | Pubmed ID: 16754721 Heparin Immobilization Reduces Thrombogenicity of Small-caliber Expanded Polytetrafluoroethylene Grafts Journal of Vascular Surgery. Mar, 2006 | Pubmed ID: 16520178 Glycoprotein Ibalpha-mediated Platelet Adhesion and Aggregation to Immobilized Thrombin Under Conditions of Flow Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2006 | Pubmed ID: 16357309 Hypofibrinolysis During Induction Treatment of Multiple Myeloma May Increase the Risk of Venous Thrombosis Thrombosis and Haemostasis. Dec, 2005 | Pubmed ID: 16411420 Elevated Plasma Tissue-type Plasminogen Activator (t-PA) and Soluble Thrombomodulin in Patients Suffering from Severe Acute Respiratory Syndrome (SARS) As a Possible Index for Prognosis and Treatment Strategy Biomedical and Environmental Sciences : BES. Aug, 2005 | Pubmed ID: 16274108 Platelet Aggregation: Involvement of Thrombin and Fibrin(ogen) Frontiers in Bioscience : a Journal and Virtual Library. 2005 | Pubmed ID: 15970513 Reduced Plasma Fibrinolytic Potential is a Risk Factor for Venous Thrombosis Blood. Feb, 2005 | Pubmed ID: 15466929 Circulating Endothelial Cells in Cancer Patients Do Not Express Tissue Factor Cancer Letters. Sep, 2004 | Pubmed ID: 15327840 Low Molecular Weight Heparin (dalteparin) is Equally Effective As Unfractionated Heparin in Reducing Coagulation Activity and Perfusion Abnormalities During the Early Treatment of Pulmonary Embolism The Journal of Laboratory and Clinical Medicine. Aug, 2004 | Pubmed ID: 15322504 Recombinant Factor VIIa Restores Aggregation of AlphaIIbbeta3-deficient Platelets Via Tissue Factor-independent Fibrin Generation Blood. Mar, 2004 | Pubmed ID: 14592825 Enhancement of Fibrinolytic Potential in Vitro by Anticoagulant Drugs Targeting Activated Factor X, but Not by Those Inhibiting Thrombin or Tissue Factor Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis. Sep, 2003 | Pubmed ID: 12960609 Recombinant Factor VIIa in Orthotopic Liver Transplantation: Influence on Parameters of Coagulation and Fibrinolysis Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis. Feb, 2003 | Pubmed ID: 12632027 Recombinant Factor VIIa Enhances Deposition of Platelets with Congenital or Acquired Alpha IIb Beta 3 Deficiency to Endothelial Cell Matrix and Collagen Under Conditions of Flow Via Tissue Factor-independent Thrombin Generation Blood. Mar, 2003 | Pubmed ID: 12411291 Haemostatic Abnormalities in Patients with Liver Disease Journal of Hepatology. Aug, 2002 | Pubmed ID: 12127437 Recombinant Factor VIIa Improves Clot Formation but Not Fibrolytic Potential in Patients with Cirrhosis and During Liver Transplantation Hepatology (Baltimore, Md.). Mar, 2002 | Pubmed ID: 11870375 Inhibition of Fibrinolysis by Recombinant Factor VIIa in Plasma from Patients with Severe Hemophilia A Blood. Jan, 2002 | Pubmed ID: 11756168 Ex Situ Normotérmica máquina de perfusión de hígados de donantes Negin Karimian1,2, Alix P.M. Matton1,2, Andrie C. Westerkamp1,2, Laura C. Burlage1,2, Sanna op den Dries1,2, Henri G.D. Leuvenink2, Ton Lisman1,2, Korkut Uygun3, James F. Markmann4, Robert J. Porte1,2 1Section of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, 2Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, 3Center of Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Burns Hospital, 4Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School JoVE 52688 Medicine
Ex Situ Normotérmica máquina de perfusión de hígados de donantes Negin Karimian1,2, Alix P.M. Matton1,2, Andrie C. Westerkamp1,2, Laura C. Burlage1,2, Sanna op den Dries1,2, Henri G.D. Leuvenink2, Ton Lisman1,2, Korkut Uygun3, James F. Markmann4, Robert J. Porte1,2 1Section of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, 2Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, 3Center of Engineering in Medicine/Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Burns Hospital, 4Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School JoVE 52688 Medicine
