Uwe Mueller Macromolecular Crystallography Helmholtz-Zentrum Berlin Biography Publications Institution JoVE Articles Uwe Mueller has not added a biography. If you are Uwe Mueller and would like to personalize this page please email our Author Liaison for assistance. Publications BioMAX - the First Macromolecular Crystallography Beamline at MAX IV Laboratory Journal of Synchrotron Radiation. Sep, 2020 | Pubmed ID: 32876619 Current Status and Future Opportunities for Serial Crystallography at MAX IV Laboratory Journal of Synchrotron Radiation. Sep, 2020 | Pubmed ID: 32876583 FragMAX: the Fragment-screening Platform at the MAX IV Laboratory Acta Crystallographica. Section D, Structural Biology. Aug, 2020 | Pubmed ID: 32744259 F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening Structure (London, England : 1993). 06, 2020 | Pubmed ID: 32413289 MXCuBE2: the Dawn of MXCuBE Collaboration Journal of Synchrotron Radiation. Mar, 2019 | Pubmed ID: 30855248 Structural Basis for Prolidase Deficiency Disease Mechanisms The FEBS Journal. 09, 2018 | Pubmed ID: 30066404 Substrate Specificity and Reaction Mechanism of Human Prolidase The FEBS Journal. 09, 2017 | Pubmed ID: 28677335 Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad Journal of Medicinal Chemistry. 11, 2016 | Pubmed ID: 27726357 Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis The Journal of Biological Chemistry. 09, 2016 | Pubmed ID: 27493206 Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin Journal of Medicinal Chemistry. 08, 2016 | Pubmed ID: 27463859 High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits Structure (London, England : 1993). 08, 2016 | Pubmed ID: 27452405 Structures of Endothiapepsin-fragment Complexes from Crystallographic Fragment Screening Using a Novel, Diverse and Affordable 96-compound Fragment Library Acta Crystallographica. Section F, Structural Biology Communications. 05, 2016 | Pubmed ID: 27139825 Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study ACS Chemical Biology. 06, 2016 | Pubmed ID: 27028906 Tuning the Flexibility in MOFs by SBU Functionalization Dalton Transactions (Cambridge, England : 2003). Mar, 2016 | Pubmed ID: 26876816 Structure Determination by Multiple-wavelength Anomalous Dispersion (MAD) at the Pr LIII Edge Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Aug, 2012 | Pubmed ID: 22869138 Facilities for Macromolecular Crystallography at The Helmholtz-Zentrum Berlin Journal of Synchrotron Radiation. May, 2012 | Pubmed ID: 22514183 The Structure of Neuroglobin at High Xe and Kr Pressure Reveals Partial Conservation of Globin Internal Cavities Biophysical Journal. Sep, 2009 | Pubmed ID: 19751675 Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry