Wang Qinwen Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine Ningbo University Biography Publications Institution JoVE Articles Wang Qinwen has not added a biography. If you are Wang Qinwen and would like to personalize this page please email our Author Liaison for assistance. Publications Eckmaxol, a Phlorotannin Extracted from Ecklonia Maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly Via Directly Acting on Glycogen Synthase Kinase 3β ACS Chemical Neuroscience. Apr, 2018 | Pubmed ID: 29608860 Tacrine(10)-hupyridone, a Dual-binding Acetylcholinesterase Inhibitor, Potently Attenuates Scopolamine-induced Impairments of Cognition in Mice Metabolic Brain Disease. Mar, 2018 | Pubmed ID: 29564727 Taxifolin Prevents β-amyloid-induced Impairments of Synaptic Formation and Deficits of Memory Via the Inhibition of Cytosolic Phospholipase A/prostaglandin E Content Metabolic Brain Disease. Mar, 2018 | Pubmed ID: 29542038 Dopamine Receptor D4 Promoter Hypermethylation Increases the Risk of Drug Addiction Experimental and Therapeutic Medicine. Feb, 2018 | Pubmed ID: 29434815 Bisphenol-A Antagonizes the Rapidly Modulating Effect of DHT on Spinogenesis and Long-term Potentiation of Hippocampal Neurons Chemosphere. Mar, 2018 | Pubmed ID: 29278848 Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice Frontiers in Molecular Neuroscience. 2017 | Pubmed ID: 29234273 5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro Molecules (Basel, Switzerland). Oct, 2017 | Pubmed ID: 28974023 Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly Via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells Oxidative Medicine and Cellular Longevity. 2017 | Pubmed ID: 28928905 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma Sp. HPQJ-34 Marine Drugs. Aug, 2017 | Pubmed ID: 28825620 Neuropeptide VGF C-Terminal Peptide TLQP-62 Alleviates Lipopolysaccharide-Induced Memory Deficits and Anxiety-like and Depression-like Behaviors in Mice: The Role of BDNF/TrkB Signaling ACS Chemical Neuroscience. Sep, 2017 | Pubmed ID: 28594546 The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation Neural Plasticity. 2017 | Pubmed ID: 28255459 Elevated OPRD1 Promoter Methylation in Alzheimer's Disease Patients PloS One. 2017 | Pubmed ID: 28253273 Curcumin Attenuates Surgery-induced Cognitive Dysfunction in Aged Mice Metabolic Brain Disease. Feb, 2017 | Pubmed ID: 28224377 Association of OPRK1 and OPRM1 Methylation with Mild Cognitive Impairment in Xinjiang Han and Uygur Populations Neuroscience Letters. Jan, 2017 | Pubmed ID: 27838450 SB203580 Reverses Memory Deficits and Depression-like Behavior Induced by Microinjection of Aβ1-42 into Hippocampus of Mice Metabolic Brain Disease. Feb, 2017 | Pubmed ID: 27488110 Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis Via Concurrently Inhibiting GSK3β and the ERK Pathway Cellular and Molecular Neurobiology. May, 2017 | Pubmed ID: 27412761 A Tunable Photoluminescent Composite of Cellulose Nanofibrils and CdS Quantum Dots Nanomaterials (Basel, Switzerland). Sep, 2016 | Pubmed ID: 28335292 Elevated DRD4 Promoter Methylation Increases the Risk of Alzheimer's Disease in Males Molecular Medicine Reports. Sep, 2016 | Pubmed ID: 27485706 A New Photoelectric Ink Based on Nanocellulose/CdS Quantum Dots for Screen-printing Carbohydrate Polymers. Sep, 2016 | Pubmed ID: 27185112 Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice ACS Chemical Neuroscience. Aug, 2016 | Pubmed ID: 27046396 Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in Vitro Marine Drugs. Mar, 2016 | Pubmed ID: 27023569 A Significant Association Between BDNF Promoter Methylation and the Risk of Drug Addiction Gene. Jun, 2016 | Pubmed ID: 26976342 Downregulation of Glutamate Transporter EAAT4 by Conditional Knockout of Rheb1 in Cerebellar Purkinje Cells Cerebellum (London, England). 06, 2016 | Pubmed ID: 26194056 Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits As Well As Synaptic Formation and Plasticity Impairments Via the Activation of PI3-K Pathway Molecular Neurobiology. Aug, 2016 | Pubmed ID: 26160762 OPRK1 Promoter Hypermethylation Increases the Risk of Alzheimer's Disease Neuroscience Letters. Oct, 2015 | Pubmed ID: 26300544 Population Difference in the Association of BDNF Promoter Methylation with Mild Cognitive Impairment in the Xinjiang Uygur and Han Populations Psychiatry Research. Oct, 2015 | Pubmed ID: 26292618 Population Difference in the Associations of KLOTH Promoter Methylation with Mild Cognitive Impairment in Xinjiang Uygur and Han Populations PloS One. 2015 | Pubmed ID: 26197428 Protection Against β-amyloid-induced Synaptic and Memory Impairments Via Altering β-amyloid Assembly by Bis(heptyl)-cognitin Scientific Reports. Jul, 2015 | Pubmed ID: 26194093 Association of BDNF and BCHE with Alzheimer's Disease: Meta-analysis Based on 56 Genetic Case-control Studies of 12,563 Cases and 12,622 Controls Experimental and Therapeutic Medicine. May, 2015 | Pubmed ID: 26136901 Chronic Inflammatory Pain Upregulates Expression of P2Y2 Receptor in Small-diameter Sensory Neurons Metabolic Brain Disease. Dec, 2015 | Pubmed ID: 26062804 Rapid-acting Antidepressant-like Effects of Acetyl-l-carnitine Mediated by PI3K/AKT/BDNF/VGF Signaling Pathway in Mice Neuroscience. Jan, 2015 | Pubmed ID: 25463525 PI3K/AKT/mTOR Signaling-mediated Neuropeptide VGF in the Hippocampus of Mice is Involved in the Rapid Onset Antidepressant-like Effects of GLYX-13 The International Journal of Neuropsychopharmacology. Dec, 2014 | Pubmed ID: 25542689 Elevation of Peripheral BDNF Promoter Methylation Links to the Risk of Alzheimer's Disease PloS One. 2014 | Pubmed ID: 25364831 Brilliant Blue G Improves Cognition in an Animal Model of Alzheimer's Disease and Inhibits Amyloid-β-induced Loss of Filopodia and Dendrite Spines in Hippocampal Neurons Neuroscience. Oct, 2014 | Pubmed ID: 25193238 Inhibition of Lung Tumor Growth by Targeting EGFR/VEGFR-Akt/NF-κB Pathways with Novel Theanine Derivatives Oncotarget. Sep, 2014 | Pubmed ID: 25138052 Investigation into the Promoter DNA Methylation of Three Genes (CAMK1D, CRY2 and CALM2) in the Peripheral Blood of Patients with Type 2 Diabetes Experimental and Therapeutic Medicine. Aug, 2014 | Pubmed ID: 25009623 Elevated CpG Island Methylation of GCK Gene Predicts the Risk of Type 2 Diabetes in Chinese Males Gene. Sep, 2014 | Pubmed ID: 24992032 Rosiglitazone Prevents the Memory Deficits Induced by Amyloid-beta Oligomers Via Inhibition of Inflammatory Responses Neuroscience Letters. Aug, 2014 | Pubmed ID: 24933538 Effects of Acidic Oligosaccharide Sugar Chain on Amyloid Oligomer-induced Impairment of Synaptic Plasticity in Rats Metabolic Brain Disease. Sep, 2014 | Pubmed ID: 24723110 Antidepressant-like Effects of the Phosphodiesterase-4 Inhibitor Etazolate and Phosphodiesterase-5 Inhibitor Sildenafil Via Cyclic AMP or Cyclic GMP Signaling in Mice Metabolic Brain Disease. Sep, 2014 | Pubmed ID: 24705918 Optimized Treatment with RF Thermotherapy and Immunotherapy Combined with CyberKnife for Advanced High-risk Tumors: A Clinical Trial Report Biomedical Reports. Mar, 2014 | Pubmed ID: 24649104 The VGF-derived Peptide TLQP62 Produces Antidepressant-like Effects in Mice Via the BDNF/TrkB/CREB Signaling Pathway Pharmacology, Biochemistry, and Behavior. May, 2014 | Pubmed ID: 24631486 Meta-analyses Between 18 Candidate Genetic Markers and Overweight/obesity Diagnostic Pathology. Mar, 2014 | Pubmed ID: 24621099 [Research Process of the Neuropeptide VGF As a Novel Antidepressant Regulatory Factor] Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University. Feb, 2014 | Pubmed ID: 24589613 Landscape of the Relationship Between Type 2 Diabetes and Coronary Heart Disease Through an Integrated Gene Network Analysis Gene. Apr, 2014 | Pubmed ID: 24508273 Etazolate Abrogates the Lipopolysaccharide (LPS)-induced Downregulation of the CAMP/pCREB/BDNF Signaling, Neuroinflammatory Response and Depressive-like Behavior in Mice Neuroscience. Mar, 2014 | Pubmed ID: 24434771 Exposure to Bisphenol-A Affects Fear Memory and Histone Acetylation of the Hippocampus in Adult Mice Hormones and Behavior. Feb, 2014 | Pubmed ID: 24333847 Rosiglitazone Prevents Amyloid-β Oligomer-induced Impairment of Synapse Formation and Plasticity Via Increasing Dendrite and Spine Mitochondrial Number Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24150104 Chronic Pre-treatment with Memantine Prevents Amyloid-beta Protein-mediated Long-term Potentiation Disruption Neural Regeneration Research. Jan, 2013 | Pubmed ID: 25206371 Meta-analyses of 8 Polymorphisms Associated with the Risk of the Alzheimer's Disease PloS One. 2013 | Pubmed ID: 24039871 The Preventive Effect of NR2B and NR2D-containing NMDAR Antagonists on Aβ-induced LTP Disruption in the Dentate Gyrus of Rats Metabolic Brain Disease. Dec, 2013 | Pubmed ID: 23975536 Genetic Associations with Diabetes: Meta-analyses of 10 Candidate Polymorphisms PloS One. 2013 | Pubmed ID: 23922971 Gender-dependent MiR-375 Promoter Methylation and the Risk of Type 2 Diabetes Experimental and Therapeutic Medicine. Jun, 2013 | Pubmed ID: 23837055 No Association Between IRS‑1 Promoter Methylation and Type 2 Diabetes Molecular Medicine Reports. Sep, 2013 | Pubmed ID: 23828647 Phosphodiesterase-5 Inhibitor Sildenafil Prevents Neuroinflammation, Lowers Beta-amyloid Levels and Improves Cognitive Performance in APP/PS1 Transgenic Mice Behavioural Brain Research. Aug, 2013 | Pubmed ID: 23685322 Stromal Cell-derived Factor-1 and Vascular Endothelial Growth Factor As Biomarkers for Lymph Node Metastasis and Poor Cancer-specific Survival in Prostate Cancer Patients After Radical Prostatectomy Urologic Oncology. Apr, 2013 | Pubmed ID: 21367627 Activation of α7 Nicotinic Acetylcholine Receptors Persistently Enhances Hippocampal Synaptic Transmission and Prevents Aß-mediated Inhibition of LTP in the Rat Hippocampus European Journal of Pharmacology. Feb, 2012 | Pubmed ID: 22200627 Small-molecule Conversion of Toxic Oligomers to Nontoxic β-sheet-rich Amyloid Fibrils Nature Chemical Biology. Nov, 2011 | Pubmed ID: 22101602 Presynaptic Impairment in Niemann-Pick C1-deficient Neurons: Not Dependent on Presence of Glial Cells Neuroscience Letters. May, 2011 | Pubmed ID: 21507342 Regulation of VEGF, MMP-9 and Metastasis by CXCR4 in a Prostate Cancer Cell Line Cell Biology International. Sep, 2011 | Pubmed ID: 21306303 Induction of Autophagy-dependent Apoptosis by the Survivin Suppressant YM155 in Prostate Cancer Cells Cancer Letters. Mar, 2011 | Pubmed ID: 21220185 Protection Against Aβ-mediated Rapid Disruption of Synaptic Plasticity and Memory by Memantine Neurobiology of Aging. Apr, 2011 | Pubmed ID: 19446369 病理激活通过 N-甲基-D-天冬氨酸受体与快速关闭率由新型多功能二聚体之二 （丙） 缺乏竞争力封锁的神经保护作用-cognitin。 The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20404346 Novel Anti-Alzheimer's Dimer Bis(7)-cognitin: Cellular and Molecular Mechanisms of Neuroprotection Through Multiple Targets Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2009 | Pubmed ID: 19110209 Cyclooxygenase-2 Inhibition Improves Amyloid-beta-mediated Suppression of Memory and Synaptic Plasticity Brain : a Journal of Neurology. Mar, 2008 | Pubmed ID: 18292081 Alpha V Integrins Mediate Beta-amyloid Induced Inhibition of Long-term Potentiation Neurobiology of Aging. Oct, 2008 | Pubmed ID: 17442458 Beta-amyloid Inhibition of Long-term Potentiation is Mediated Via Tumor Necrosis Factor The European Journal of Neuroscience. Dec, 2005 | Pubmed ID: 16324117 Mechanisms of the Inhibitory Effects of Amyloid Beta-protein on Synaptic Plasticity Experimental Gerontology. Nov-Dec, 2004 | Pubmed ID: 15582282 Beta-amyloid-mediated Inhibition of NMDA Receptor-dependent Long-term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2004 | Pubmed ID: 15240796 Block of Long-term Potentiation by Naturally Secreted and Synthetic Amyloid Beta-peptide in Hippocampal Slices is Mediated Via Activation of the Kinases C-Jun N-terminal Kinase, Cyclin-dependent Kinase 5, and P38 Mitogen-activated Protein Kinase As Well As Metabotropic Glutamate Receptor Type 5 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2004 | Pubmed ID: 15056716 Mycophenolate Mofetil Vs Cyclophosphamide Therapy for Patients with Diffuse Proliferative Lupus Nephritis Chinese Medical Journal. May, 2002 | Pubmed ID: 12133539 用斑点印迹分析 A11-positive β淀粉样寡聚物的制备与评价 Huang Chunhui1,2, Xu Dilin1, Zhang Ke1, Shentu Jieyi2, Yan Sicheng1, Wu Dapeng3, Wang Qinwen1, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, 3School of Materials Science and Chemical Engineering, Ningbo University JoVE 57592 Biochemistry 使用荧光素二乙酸酯 - 碘化丙啶双重染色在小脑颗粒神经元培养中评估神经元活力 Lin Jiajia*1, Mak Shinghung*2, Zheng Jiacheng1, Wang Jialing1, Xu Dilin1, Hu Shengquan2, Zhang Zaijun3, Wang Qinwen1, Han Yifan2,4, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, 3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, 4International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong JoVE 55442 Neuroscience
用斑点印迹分析 A11-positive β淀粉样寡聚物的制备与评价 Huang Chunhui1,2, Xu Dilin1, Zhang Ke1, Shentu Jieyi2, Yan Sicheng1, Wu Dapeng3, Wang Qinwen1, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, 3School of Materials Science and Chemical Engineering, Ningbo University JoVE 57592 Biochemistry
使用荧光素二乙酸酯 - 碘化丙啶双重染色在小脑颗粒神经元培养中评估神经元活力 Lin Jiajia*1, Mak Shinghung*2, Zheng Jiacheng1, Wang Jialing1, Xu Dilin1, Hu Shengquan2, Zhang Zaijun3, Wang Qinwen1, Han Yifan2,4, Cui Wei1,2 1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, 3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, 4International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong JoVE 55442 Neuroscience
