Other Publications (1)
Articles by Winnie Enns in JoVE
Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis Winnie Enns1, Anna von Rossum1, Jonathan Choy1 1Department of Molecular Biology and Biochemistry, Simon Fraser University We describe a protocol for aortic interposition grafting in mice. The goal of the protocol is to provide a model with which to study pathological processes and therapeutic strategies relevant to alloimmune reactions in arteries and the resultant arterial changes that contribute to organ transplant failure.
Other articles by Winnie Enns on PubMed
Bim Regulates Alloimmune-mediated Vascular Injury Through Effects on T-cell Activation and Death Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2014 | Pubmed ID: 24700126 Bim is a proapoptotic Bcl-2 protein known to downregulate immune responses and to also be required for antigen-induced T-cell activation. However, it is not known how the effect of Bim on these offsetting processes determines the outcome of allogeneic immune responses. We have defined the role of Bim in regulating alloantigen-driven T-cell responses in a model of vascular rejection.