Yasuo Ihara

Publications

• Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy
  Frontiers in Neuroscience. 2018  |   Pubmed ID: 29973863
• Distinct Deposition of Amyloid-β Species in Brains with Alzheimer's Disease Pathology Visualized with MALDI Imaging Mass Spectrometry
  Acta Neuropathologica Communications. 10, 2017  |   Pubmed ID: 29037261
• Semagacestat Is a Pseudo-Inhibitor of γ-Secretase
  Cell Reports. Oct, 2017  |   Pubmed ID: 28978478
• Alanine Substitutions in the GXXXG Motif Alter C99 Cleavage by γ-secretase but Not Its Dimerization
  Journal of Neurochemistry. 03, 2017  |   Pubmed ID: 28032911
• Curcumin Improves Tau-induced Neuronal Dysfunction of Nematodes
  Neurobiology of Aging. Mar, 2016  |   Pubmed ID: 26923403
• Toxic Tau Oligomer Formation Blocked by Capping of Cysteine Residues with 1,2-dihydroxybenzene Groups
  Nature Communications. Dec, 2015  |   Pubmed ID: 26671725
• The A673T Mutation in the Amyloid Precursor Protein Reduces the Production of β-amyloid Protein from Its β-carboxyl Terminal Fragment in Cells
  Acta Neuropathologica Communications. Nov, 2015  |   Pubmed ID: 26531305
• Identification of Key Amino Acids Responsible for the Distinct Aggregation Properties of Microtubule-associated Protein 2 and Tau
  Journal of Neurochemistry. Oct, 2015  |   Pubmed ID: 26134402
• Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
  Journal of Neuropathology and Experimental Neurology. Jul, 2014  |   Pubmed ID: 24918637
• Lack of Genetic Association Between TREM2 and Late-onset Alzheimer's Disease in a Japanese Population
  Journal of Alzheimer's Disease : JAD. 2014  |   Pubmed ID: 24762945
• The Homologous Carboxyl-terminal Domains of Microtubule-associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles
  PloS One. 2014  |   Pubmed ID: 24587039
• γ-Secretase Associated with Lipid Rafts: Multiple Interactive Pathways in the Stepwise Processing of β-carboxyl-terminal Fragment
  The Journal of Biological Chemistry. Feb, 2014  |   Pubmed ID: 24375443
• Substrate Ectodomain is Critical for Substrate Preference and Inhibition of γ-secretase
  Nature Communications. 2013  |   Pubmed ID: 24108142
• Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-secretase Inhibition by Ginsenoside (20S)-Rg3
  The Journal of Biological Chemistry. Jul, 2013  |   Pubmed ID: 23723072
• SORL1 is Genetically Associated with Late-onset Alzheimer's Disease in Japanese, Koreans and Caucasians
  PloS One. 2013  |   Pubmed ID: 23565137
• Suspected Limited Efficacy of γ-secretase Modulators
  Neurobiology of Aging. Apr, 2013  |   Pubmed ID: 23058852
• The Ubiquitin-proteasome System and the Autophagic-lysosomal System in Alzheimer Disease
  Cold Spring Harbor Perspectives in Medicine. Aug, 2012  |   Pubmed ID: 22908190
• Central Nervous System-specific Deletion of Transcription Factor Nrf1 Causes Progressive Motor Neuronal Dysfunction
  Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jun, 2011  |   Pubmed ID: 21554501
• Gamma-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of Beta-carboxyl Terminal Fragment
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009  |   Pubmed ID: 19828817
• GAB2 is Not Associated with Late-onset Alzheimer's Disease in Japanese
  European Journal of Human Genetics : EJHG. May, 2009  |   Pubmed ID: 18854865
• [Overview on Alzheimer's Disease]
  Rinsho Shinkeigaku = Clinical Neurology. Nov, 2007  |   Pubmed ID: 18210830