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Assessing Hepatic Steatosis with 3D Fluorescence Lipid Droplet Reconstruction

June 2nd, 2023
1,2,3,4, 1,2,3, 1,2,3, 1,2,3, 1,2,3,4
1Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 2Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3Clinical Academic Center of Coimbra (CACC), 4Polytechnic Institute of Coimbra, Coimbra Health School

Summary
Automatic Translation

在本文中，我们展示了一种优化的基于BODIPY 493 / 503荧光的方案，用于肝组织中的脂滴表征。通过使用正交投影和3D重建，荧光团可以成功区分微泡和大泡脂肪变性，并且可能代表用于肝脂肪变性评估的经典组织学方案的补充方法。

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