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Ivacaftor와 ivacaftor-lumacaftor는 두 개의 새로운 CF 약물. 그러나, 여전히 그들의 PK/PD 및 약리학에 대 한 이해의 부족이입니다. 우리는 주요 대사 산물, ivacaftor 및 lumacaftor의 동시 분석에 대 한 최적화 된 HPLC MS 기법 제시.