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Bioengineering

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JoVE Journal Bioengineering
Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections
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Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections

Article DOI: 10.3791/56492-v • 12:21 min • October 31st, 2017
October 31st, 2017 •
*1, *2,3, 2,3,4,5
1Department of Chemistry, University of Louisville, 2Department of Pharmacology and Toxicology, University of Louisville, 3Center for Predictive Medicine, University of Louisville, 4Department of Microbiology and Immunology, University of Louisville, 5Department of Bioengineering, University of Louisville
* These authors contributed equally

Kapitel

Summary
Automatic Translation

This manuscript describes the procedure to fabricate and characterize Griffithsin-modified poly(lactic-co-glycolic acid) electrospun fibers that demonstrate potent adhesive and antiviral activity against human immunodeficiency virus type 1 infection in vitro. Methods used to synthesize, surface-modify, and characterize the resulting morphology, conjugation, and desorption of Griffithsin from surface-modified fibers are described.

Tags

Fabrication Characterization Griffithsin-modified Fiber Scaffolds Prevention Sexually Transmitted Infections Drug Delivery Polylactic Acid Co-glycolic Acid Electrospun Fibers Antiviral Protein Griffithsin HIV-1 Technique Polymeric-electrospun Fibers Antiviral Activity Localized Griffithsin Implications Viral Infections Bacterial Infections Prophylactic Potential Therapeutic Potential HIV-1 Infection Prevention Weigh PLGA Scintillation Vile HFIP Polymer Suspension
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