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Espectrometría de masas enfoque para estudiar la estructura de la proteína y las interacciones en liofilizadas Polvos
JoVE Revista
Quimica
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JoVE Revista Quimica
Mass Spectrometric Approaches to Study Protein Structure and Interactions in Lyophilized Powders

Espectrometría de masas enfoque para estudiar la estructura de la proteína y las interacciones en liofilizadas Polvos

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11:14 min

April 14, 2015

DOI:

11:14 min
April 14, 2015

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Summary

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Here, we present detailed protocols for solid-state amide hydrogen/deuterium exchange mass spectrometry (ssHDX-MS) and solid-state photolytic labeling mass spectrometry (ssPL-MS) for proteins in solid powders. The methods provide high-resolution information on protein conformation and interactions in the amorphous solid-state, which may be useful in formulation design.

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