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Neuroscience

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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Article DOI: 10.3791/2330-v • 14:57 min • March 23rd, 2011
March 23rd, 2011 •
1, 2, 2,3
1Graduate Center for Gerontology, University of Kentucky College of Public Health, 2Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 3Sanders-Brown Center on Aging, University of Kentucky College of Medicine

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This article outlines procedures for preparing hippocampal slices from rats and transgenic mice for the study of synaptic alterations associated with brain aging and age-related neurodegenerative diseases, such as Alzheimer’s disease.

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Acute Hippocampal Slices Rats Transgenic Mice Synaptic Alterations Aging Amyloid Pathology Synaptic Function Plasticity Electrophysiological Techniques Cognitive Impairments Synaptic Plasticity Mechanisms Long-term Potentiation Long-term Depression Nootropic Compounds Brain Aging Alzheimer's Disease (AD) Aged Rats AD Model Mice
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