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JoVE Journal Cancer Research
CRISPR 指南对小鼠前列腺病毒传递的基因改变
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CRISPR 指南对小鼠前列腺病毒传递的基因改变

Article DOI: 10.3791/57525-v • 06:21 min • April 27th, 2018
April 27th, 2018 •
1, 1, 2, 2, 1
1Department of Clinical Medicine, Aarhus University, 2GDD, Cancer Cell Biology Program, National Cancer Research Center (CNIO)

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该协议描述了一种新建立的方法, 病毒传递到小鼠前列腺。使用 CRISPR/Cas9 技术, 基因过度表达, 或 recombinase 分娩, 该技术允许基因表达的原位改变, 并实施了新的小鼠模型前列腺癌。

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癌症研究 问题 134 前列腺癌 基因组编辑 基因治疗 基因改变 病毒传递 病毒注射 CRISPR/Cas9 腺相关病毒,体内肿瘤模型 肿瘤萌生
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