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Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Article DOI: 10.3791/1644-v • 10:11 min • October 27th, 2009
October 27th, 2009 •
1, 1, 1, 1
1Fluxion Biosciences, Inc.

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The platelet adhesion cascade takes place in the presence of shear flow, a factor not accounted for in conventional (static) well-plate assays. This article reports on a platelet-aggregation assay utilizing a microfluidic well-plate format to emulate physiological shear flow conditions.

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Platelet Adhesion Platelet Aggregation Microfluidic Flow Cells Shear Flow Well-plate Assays Microfluidic Well-plate Format Physiological Shear Flow Extracellular Proteins Collagen I Von Willebrand Factor Active Perfusion Pneumatic Pump Buffer Platelet Interactions Fluorescent Dye Flow Rates Platelet Activation Platelet Aggregation Inhibitors IC50 Dose Response Data
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