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Microfabricated Platforms for Mechanically Dynamic Cell Culture

Article DOI: 10.3791/2224-v • 15:21 min • December 26th, 2010
December 26th, 2010 •
1,2, 1,2, 1,2,3
1Department of Mechanical and Industrial Engineering, University of Toronto, 2Institute of Biomaterials and Biomedical Engineering, University of Toronto, 3Faculty of Dentistry, University of Toronto

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In this protocol, we demonstrate the fabrication of a microactuator array of vertically displaced posts on which the technology is based, and how this base technology can be modified to conduct high-throughput mechanically dynamic cell culture in both two-dimensional and three-dimensional culture paradigms.

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Microfabricated Platforms Mechanically Dynamic Cell Culture Mechanobiological Stimuli Tissue Engineering Drug Discovery Cell Biology Studies Bioreactor Technologies Mechanical Stimuli High-throughput Format Microactuator Array Vertically Displaced Posts Two-dimensional Culture Paradigms Three-dimensional Culture Paradigms
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