JoVE Journal

Neuroscience

JoVE Neuroscience includes methods and techniques for studying the brain and nervous system; also featuring potential treatments for neurological conditions and diseases.

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Live Animal Imaging and Cell Sorting Methods for Investigating Neurodegeneration in a C. elegans Excitotoxic Necrosis Model

Zelda Z Mendelowitz*^1,2, Adem Idrizi*¹, Itzhak Mano^1,2

¹Cellular, Molecular, and Biomedical Science, CUNY School of Medicine, The City University of New York (CUNY), ²PhD Program in Biology, The CUNY Graduate Center, The City University of New York (CUNY)

JoVE 61958

Methods Collection

A Rat Model of EcoHIV Brain Infection

Hailong Li¹, Kristen A. McLaurin¹, Charles F. Mactutus¹, Rosemarie M. Booze¹

¹Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina

JoVE 62137

Stereocilia Bundle Imaging with Nanoscale Resolution in Live Mammalian Auditory Hair Cells

Carolina Galeano-Naranjo^1,2, A. Catalina Veléz-Ortega¹, Gregory I Frolenkov¹

¹Department of Physiology, College of Medicine, University of Kentucky, ²Universidad Nacional de Colombia

JoVE 62104

Methods Collection

Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease

Kelly L. Stauch¹, Steven Totusek¹, Trey Farmer¹, Benjamin G. Lamberty¹, Kelsey N. Dyball¹, Mohannad A. Almikhlafi¹, Howard S. Fox¹

¹Department of Neurological Sciences, University of Nebraska Medical Center

JoVE 62002

Simultaneous Application of Transcranial Direct Current Stimulation during Virtual Reality Exposure

Mascha van 't Wout-Frank^1,2,3, Noah S. Philip^1,2,3

¹VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Medical Healthcare System, ²Department of Psychiatry and Human Behavior, Alpert Brown Medical School, ³COBRE Center for Neuromodulation, Butler Hospital

JoVE 61795

Methods Collection

Visualizing the Calcitonin Gene-Related Peptide Immunoreactive Innervation of the Rat Cranial Dura Mater with Immunofluorescence and Neural Tracing

Jia Wang*¹, Dongsheng Xu*¹, Jingjing Cui¹, Chen She¹, Hui Wang¹, Shuang Wu¹, Ling Zou¹, Jianliang Zhang¹, Wanzhu Bai¹

¹Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences

JoVE 61742

Functional Isolation of Single Motor Units of Rat Medial Gastrocnemius Muscle

Hanna Drzymała-Celichowska*^1,2, Jan Celichowski*¹

¹Department of Neurobiology, Poznań University of Physical Education, ²Department of Biochemistry, Poznań University of Physical Education

JoVE 61614

A Hydrophobic Tissue Clearing Method for Rat Brain Tissue

Kristin N. Kirchner¹, Hailong Li¹, Adam R. Denton¹, Steven B. Harrod¹, Charles F. Mactutus¹, Rosemarie M. Booze¹

¹Program in Behavioral Neuroscience, Department of Psychology, University of South Carolina

JoVE 61821

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Jerzy O. Szablowski¹, Manwal Harb¹

¹Department of Bioengineering, Rice University

JoVE 61352

Methods Collection

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Krishna Melnattur¹, Ellen Morgan¹, Vincent Duong¹, Arjan Kalra¹, Paul J. Shaw¹

¹Department of Neuroscience, Washington University School of Medicine

JoVE 62105

Methods Collection

Cerebellar Regional Dissection for Molecular Analysis

Katherine A. Hamel¹, Marija Cvetanovic¹

¹Department of Neuroscience, University of Minnesota

JoVE 61922

Methods Collection

Qualitative and Comparative Cortical Activity Data Analyses from a Functional Near-Infrared Spectroscopy Experiment Applying Block Design

Kazuya Saita^1,2, Takashi Morishita¹, Hisatomi Arima³, Toshiyasu Ogata⁴, Tooru Inoue¹

¹Department of Neurosurgery, Faculty of Medicine, Fukuoka University, ²Department of Rehabilitation Medicine, Fukuoka University Hospital, ³Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, ⁴Department of Neurology, Fukuoka University Hospital

JoVE 61836

Methods Collection

Long-Term, Serum-Free Cultivation of Organotypic Mouse Retina Explants with Intact Retinal Pigment Epithelium

Soumaya Belhadj*¹, Arianna Tolone*¹, Gustav Christensen¹, Soumyaparna Das¹, Yiyi Chen¹, François Paquet-Durand¹

¹Institute for Ophthalmic Research, University of Tübingen

JoVE 61868

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Sovannarath Pong^1,2,3, Paulo Lizano^1,2,3,4, Rakesh Karmacharya^1,3,4,5

¹Center for Genomic Medicine, Massachusetts General Hospital, ²Department of Psychiatry, Beth Israel Deaconess Medical Center, ³Chemical Biology and Therapeutic Science Program, Broad Institute of MIT and Harvard, ⁴Department of Psychiatry, Harvard Medical School, ⁵Schizophrenia and Bipolar Disorder Program, McLean Hospital

JoVE 61629

Quantification of Cerebral Perfusion using Laser Speckle Imaging and Infarct Volume using MRI in a Pre-clinical Model of Posterior Circulation Stroke

Surya C. Gnyawali¹, Debra G. Wheeler¹, Allyson L. Huttinger¹, Cole Anderson¹, Ian Mandybur¹, Catherine Lee¹, Caitlin Hatten¹, Jenna Boue², Matthew Joseph³, Shahid M. Nimjee^1,2,4

¹Department of Neurological Surgery, The Ohio State University Medical Center, ²Department of Anatomy, The Ohio State University Medical Center, ³Department of Internal Medicine, The Ohio State University Medical Center, ⁴Department of Radiology, The Ohio State University Medical Center

JoVE 61673

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Genilso Gava-Junior*¹, Cláudio Roque*¹, Julieta Mendes-Oliveira¹, Ana C Bernardino¹, Inês Serrenho¹, Joel P Pires¹, Graça Baltazar^1,2

¹Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, ²Faculdade de Ciências da Saúde, Universidade da Beira Interior

JoVE 61388

Methods Collection

Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions

Benedetta Assetta*¹, Changyong Tang*^1,2, Jing Bian*³, Ryan O'Rourke¹, Kevin Connolly¹, Thomas Brickler³, Sundari Chetty^3,4, Yu-Wen Alvin Huang^1,5,6

¹Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, ²Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, ³Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, ⁴Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, ⁵Department of Neurology, Warren Alpert Medical School of Brown University, ⁶Center for Translational Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science and Brown Institute for Translational Science, Brown University

JoVE 61778

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

Aric F. Logsdon*^1,2, Brandon P. Lucke-Wold*³, Ryan C. Turner*⁴, Sean M. Collins⁵, Evan L. Reeder⁵, Jason D. Huber⁴, Charles L. Rosen⁶, Matthew J. Robson*⁵, Florian Plattner*⁷

¹Geriatrics Research Education and Clinical Center, Veterans Affairs, ²Division of Gerontology and Geriatric Medicine, University of Washington, ³Department of Neurosurgery, University of Florida, ⁴Department of Neurosurgery, West Virginia University, ⁵Division of Pharmaceutical Sciences, University of Cincinnati, ⁶Central Illinois Neuro Health Sciences, Bloomington, IL, ⁷Neuro-research, Dallas, TX

JoVE 61244

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

María Portela-Lomba^1,3, Diana Simón¹, Cristina Russo², Javier Sierra¹, María Teresa Moreno-Flores³

¹Facultad de CC Experimentales, Universidad Francisco de Vitoria, ²Dept. Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, ³Dept. Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid

JoVE 61863

Super-Resolution Imaging to Study Co-Localization of Proteins and Synaptic Markers in Primary Neurons

Luca Russo¹, Carmina Natale¹, Andrea Conz¹, Joe Kelk², Elena Restelli², Roberto Chiesa², Mario Salmona¹, Luana Fioriti^2,3, Luca Colnaghi¹

¹Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, ²Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, ³Dulbecco Telethon Institute, Istituto di Ricerche Farmacologiche Mario Negri IRCCS

JoVE 61434

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Dmitry Frank*¹, Benjamin F. Gruenbaum*², Julia Grinshpun¹, Israel Melamed³, Olena Severynovska⁴, Ruslan Kuts¹, Michael Semyonov¹, Evgeni Brotfain¹, Alexander Zlotnik¹, Matthew Boyko¹

¹Department of Anesthesiology and Critical Care, Soroka Medical Center, Ben-Gurion University of the Negev, ²Department of Anesthesiology, Yale University School of Medicine, ³Department of Neurosurgery, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, ⁴Department of Physiology, Faculty of Biology, Ecology and Medicine, Dnepropetrovsk State University