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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Article DOI: 10.3791/50933-v • 06:43 min • December 7th, 2013
December 7th, 2013 •
1, 1, 2, 2, 1,2
1Department of Biochemistry and Biomedical Sciences, McMaster University, 2Thrombosis and Atherosclerosis Research Institute, McMaster University

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We describe procedures to quantify and characterize atherosclerotic lesions in mouse models using precision sectioning of the aortic sinus and ascending aorta combined with histochemical and immunohistochemical analysis.

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Quantitative Analysis Characterization Atherosclerotic Lesions Murine Aortic Sinus Myocardial Infarction Stroke Mouse Models Molecular Pathophysiology Cellular Pathophysiology Cross-sectional Area Total Volume Atherosclerotic Progression Treatment Groups Valve Leaflets Sectioning Angle Staining Methods Atherogenesis
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