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A Model to Simulate Clinically Relevant Hypoxia in Humans

Article DOI: 10.3791/54933-v • 09:54 min • December 22nd, 2016
December 22nd, 2016 •
1, 1, 2, 1, 3, 4, 1
1Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Bonn, 2Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 3Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, 4Institute of Physiology 2, University of Bonn

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요약
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Hypoxia simulation in humans has usually been performed by inhaling hypoxic gas mixtures. For this study, apneic divers were used to simulate dynamic hypoxia in humans. Additionally, physiological changes in desaturation and re-saturation kinetics were evaluated with non-invasive tools such as Near-Infrared-Spectroscopy (NIRS) and peripheral oxygenation saturation (SpO2).

Tags

Simulate Clinically Relevant Hypoxia Apnoea Hypercapnia Intermittent Apnoea Sleep Apnoea Airway Obstruction Physiological Mechanisms Hypoxic Damage Dynamic Model Heart Rate Circulation Technical Devices NIRS Electrode Peripheral Tissue Oxygenation Cerebral Tissue Oxygenation
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