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Eine kinetische Fluoreszenz basierenden Ca2 + Mobilisierung Assay, G-Protein-gekoppelten Rezeptor-Agonisten und Antagonisten allosterische Modulatoren zu identifizieren
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Eine kinetische Fluoreszenz basierenden Ca2 + Mobilisierung Assay, G-Protein-gekoppelten Rezeptor-Agonisten und Antagonisten allosterische Modulatoren zu identifizieren

Article DOI: 10.3791/56780-v • 07:41 min • February 20th, 2018
February 20th, 2018 •
1, 1, 1, 1, 1
1Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven

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Beschriebenen zelluläre Assay dient zur Identifizierung der CXC-Chemokin-Rezeptor 4 (CXCR4)-interaktiver Agenten, die hemmen oder fördern, kompetitiv oder allosterically, die intrazelluläre Ca2 + Release von CXCR4 Aktivierung initiiert.

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Medizin Ausgabe 132 G-Protein-gekoppelten Rezeptor Chemokin CXC-Chemokin-Rezeptor 4 Fluoreszenz zellbasierte Assays Ca2 + Mobilisierung Agonist Antagonist Arzneimittelforschung allosterische Modulator kleine Moleküle
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