Chapter 4
Protein Function
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their…
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most…
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is…
Enzymes require additional components for proper function. There are two such classes of molecules: cofactors and coenzymes. Cofactors are metallic…
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the…
Binding sites linkages can regulate a protein's function. For example, enzyme activity is often regulated through a feedback mechanism…
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These…
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation,…
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an…
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s…
Protein kinases are able to govern large-scale cellular changes in response to complex arrays of stimuli, and much effort has been directed at…
Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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Proteins are an important class of biological macromolecules that play many key roles in cellular functions including gene expression, catalyzing…