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Capítulo 10
Expressão Genética Específica para Células
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same…
A Regulação da Expressão Ocorre em Várias Etapas
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves…
Sequências Cis-regulatórias
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These…
Vinculação Cooperativa de Reguladores de Transcrição
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences…
Ativadores e Repressores Transcricionais Procarióticos
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the…
Operões
Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related…
A Região do Promotor Eucariótico
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start…
Coativadores e Corepressores
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in…
Ativadores de Transcrição Eucariótica
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate…
Inibidores da Transcrição Eucariótica
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding…
Controle de Gene Combinatório
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of…
Células Estaminais Pluripotentes Induzidas
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific…
Reguladores Mestres de Transcrição
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often…
Regulação Epigenética
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases…
Impressão e Herança Genômica
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both…
Identificar Sites de Factor de transcrição Olig2 vinculação genômica em agudamente purificado PDGFRα + células por imunoprecipitação da cromatina Low-célula sequenciamento análise
In mammalian cells, gene transcription is regulated in a cell type specific manner by the interactions of transcriptional factors with genomic DNA.…
Uma plataforma de metil-Seq do rato para identificar alterações epigenéticas associadas com exposição de estresse
As genomes of a wider variety of animals become available, there is an increasing need for tools that can capture dynamic epigenetic changes in these…
Perfil de expressão gênica específica do tipo de célula no fígado do mouse
Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental…

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