Chapter 5
Acids and Bases
In 1923, the Brønsted–Lowry definition of acids and bases was proposed by Johannes Brønsted and Thomas Lowry. According to this…
This lesson delves into Lewis acids and bases in the context of the octet rule for electron-deficient compounds. Here, the concept is discussed,…
In any solution, the value of pKa indicates whether an acid is completely dissociated or not. A negative pKa corresponds to a stronger acid, whereas…
An acid can be deprotonated to form a conjugate base or an anion. If the produced anion is more stable, then the acid is stronger. On the contrary,…
The direct functionalization of C-H bonds is an important and long standing goal in organic chemistry. Such transformations can be very powerful in…
Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
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Lewis acid-activation of carbonyl-containing substrates is a fundamental basis for facilitating transformations in organic chemistry. Historically,…
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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This protocol presents the use of Lewis acidic multi-role reagents to circumvent kinetic trapping observed during the self-assembly of…