Chapter 4
Pharmacodynamics
Principles of Drug Action
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Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels,…
Targets for Drug Action: Overview
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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and…
Signal Transduction: Overview
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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as…
Transducer Mechanism: G Protein–Coupled Receptors
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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an…
Ligand-Gated Ion Channel Receptor: Gating Mechanism
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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They…
Transducer Mechanism: Enzyme-Linked Receptors
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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug…
Transducer Mechanism: Nuclear Receptors
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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in…
Dose-Response Relationship: Overview
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Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many…
Dose-Response Relationship: Potency and Efficacy
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The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective…
Dose-Response Relationship: Selectivity and Specificity
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Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The…
Therapeutic Index
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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the…
Drug-Receptor Interaction: Agonist
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Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it…
Drug-Receptor Interaction: Antagonist
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An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or…
Combined Effects of Drugs: Antagonism
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The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug…
Combined Effects of Drugs: Synergism
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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also…
Spare Receptors
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Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare…
Quantitative Aspects of Drug-Receptor Interaction
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The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are…
The Two-State Receptor Model
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The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to…
Desensitization and Tachyphylaxis
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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a…
G-Protein-Coupled Receptors (GPCRs) are a large family of transmembrane receptors that play critical roles in normal cellular physiology and…
Label-free impedance-based assays are increasingly used to non-invasively study ligand-induced GPCR activation in cell culture experiments. The…