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Editorial

Die 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemie 2008

Published: January 13, 2010 doi: 10.3791/1575

Summary

Amerikanische Biochemiker Roger Tsien teilten sich die 2008 der Nobelpreis in Chemie mit Martin Chalfie und Osamu Shimomura für die Entdeckung und die Entwicklung des Green Fluorescent Protein (GFP). Tsien dramatisch verbessert die Wildtyp-GFP was zu einer erhöhten Fluoreszenz, erhöhte Photostabilität, und eine Verschiebung in der großen Erregung peak to 488 nm (Matching FITC).

References

  1. Roger Y. Tsien - Autobiography [Internet]. , The Nobel Foundation. Available from: http://nobelprize.org/nobel_prizes/chemistry/laureates/2008/tsien-autobio.html (c2003).
  2. Nobel Lecture by Roger Y. Tsien- Media Player [Internet]. , The Nobel Foundation. Available from: http://nobelprize.org/mediaplayer/index.php?id=1070 (c2003).
  3. Davenport, D., Nicol, J. A. C. Luminescence of hydromedusae. Proc. R. Soc. 144, 399-411 (1955).
  4. Shimomura, O., Johnson, F. H., Saiga, Y. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan. Aequorea. J. Cell. Comp. Physiol. 59, 223-229 (1962).
  5. Tsien, R. Y. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 19 (11), 2396-2404 (1980).
  6. Heim, R., Cubitt, A., Tsien, R. Y. Improved green fluorescence. Nature. 373, 663-664 (1995).

Tags

Cellular Biology Ausgabe 35 GFP Green Fluorescent Protein IFPS Quallen PKA Calmodulin
Die 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemie 2008
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Tsien, R. Y. The 2009 Lindau NobelMore

Tsien, R. Y. The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008. J. Vis. Exp. (35), e1575, doi:10.3791/1575 (2010).

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