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Medicine

多发性硬化症性能测试(MSPT):一个iPad为基础的残疾评估工具

doi: 10.3791/51318 Published: June 30, 2014

Abstract

在多发性硬化症神经和神经心理缺陷和残疾的精确测量是具有挑战性的。我们提出一个新的测试,多发性硬化症性能测试(MSPT),它代表了一种新的方法来量化MS相关的残疾。该MSPT需要在计算机技术,信息技术,生物力学和临床测量科学进步的好处。所得MSPT代表的基于计算机的平台为MS严重性精确,有效的测量。基于,但延长了多发性硬化症功能复合(MSFC),则MSPT提供的行走速度,平衡,手灵巧度,视觉功能和认知加工速度精确,定量数据。该MSPT由51例MS患者和49名健康对照(HC)进行测试。 MSPT得分均高重现性,与技术人员管理的考试成绩密切相关,歧视MS从HC和轻度MS严重的,并与患者报告结果相关秒。与技术人员为基础的测试相比,可靠性,灵敏性和临床意义MSPT比分措施是有利的。该MSPT是收集MS残疾的结果数据,病人护理和研究的一个潜在的变革方式。因为该测试是基于计算机的,测试性能,可在传统的或新颖的方式进行分析,并可以将数据直接输入到研究或临床数据库。该MSPT可以广为传播,以在实践中设置的医生谁没有连接到临床试验表现网站或谁正在练习在农村设置,大大提高进入临床试验的临床医生和患者。该MSPT能够适应出门诊的设置,如病人的家庭,从而提供更有意义的现实世界的数据。该MSPT代表neuroperformance测试的新典范。这种方法可以有标准化的计算机适应t关于在MS临床护理和研究同样变革性的影响令人感兴趣已在教育领域,有明确的潜力,加快临床护理和研究进展。

Materials

Name Company Catalog Number Comments
9-Hole Peg Test Kit Rolyan A8515
Apple iPad with Retina Display (16 GB, Wi-Fi, White) Apple MD513LL/A
CD Player Non-brand specific
iPad Body Belt Motion Med LLC RMBB001 Special order for The Cleveland Clinic
LCVA Wall Chart Precision Vision 2180
Music Stand Non-brand specific
PASAT Audio CD PASAT.US English
SDMT Test Materials WPS W-129
Upper Extremity Overlay Apparatus Motion Med LLC PB002 Special order for The Cleveland Clinic

DOWNLOAD MATERIALS LIST

References

  1. Fisher, E. Multiple Sclerosis Therapeutics. 173-199 (2007).
  2. Whitaker, J. N., McFarland, H. F., Rudge, P., Reingold, S. C. Outcomes assessment in multiple sclerosis clinical trials: A critical analysis. Multiple Scerlosis: Clinical Issues. 1, 37-47 (1995).
  3. Rudick, R., et al. Clinical outcomes assessment in multiple sclerosis. Ann. Neurol. 40, 469-479 (1996).
  4. Cohen, J. A., Reingold, S. C., Polman, C. H., Wolinsky, J. S. Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects. Lancet Neurol. 11, 467-476 (2012).
  5. Kurtzke, J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 33, 1444-1452 (1983).
  6. Willoughby, E. W., Paty, D. W. Scales for rating impairment in multiple sclerosis: a critique. Neurology. 38, 1793-1798 (1988).
  7. Rudick, R., et al. Recommendations from the National Multiple Sclerosis Society Clinical Outcomes Assessment Task Force. Ann. Neurol. 42, 379-382 (1997).
  8. Cutter, G. R., et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain. 122 (Pt 5), 871-882 (1999).
  9. Gronwall, D. M. A. Paced auditory serial-addition task: A measure of recovery from concussion. Percept Mot Skills. 44, 367-373 (1977).
  10. Rao, S. M., Leo, G. J., Bernardin, L., Unverzagt, F. Cognitive dysfunction in multiple sclerosis I. Frequency, patterns, and prediction. Neurology. 41, 685-691 (1991).
  11. Ontaneda, D., LaRocca, N., Coetzee, T., Rudick, R. Revisiting the multiple sclerosis functional composite proceedings from the National Multiple Sclerosis Society (NMSS) Task Force on Clinical Disability Measures. Mult. Scler. 18, 1074-1080 (2012).
  12. Balcer, L. J., et al. New low-contrast vision charts: reliability and test characteristics in patients with multiple sclerosis. Mult. Scler. 6, 163-171 (2000).
  13. Smith, A. Symbol-Digit Modalities Test Manual. Western Psychological Services. (1973).
  14. Benedict, R. H., et al. Reliability and equivalence of alternate forms for the Symbol Digit Modalities Test: implications for multiple sclerosis clinical trials. Mult. Scler. 18, 1320-1325 (2012).
  15. Rudick, R. A., LaRocca, N., Hudson, L. D. Multiple Sclerosis Outcome Assessments Consortium: Genesis and initial project plan. (2013).
  16. Polman, C. H., et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 69, 292-302 (2011).
  17. Schwartz, C. E., Vollmer, T., Lee, H. Reliability and validity of two self-report measures of impairment and disability for MS. North American Research Consortium on Multiple Sclerosis Outcomes Study Group. Neurology. 52, 63-70 (1999).
  18. Marrie, R. A., Goldman, M. Validity of performance scales for disability assessment in multiple sclerosis. Mult. Scler. 13, 1176-1182 (2007).
  19. Cella, D., et al. The neurology quality-of-life measurement initiative. Arch. Phys. Med. Rehabil. 92, (2011).
多发性硬化症性能测试(MSPT):一个iPad为基础的残疾评估工具
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Cite this Article

Rudick, R. A., Miller, D., Bethoux, F., Rao, S. M., Lee, J. C., Stough, D., Reece, C., Schindler, D., Mamone, B., Alberts, J. The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool. J. Vis. Exp. (88), e51318, doi:10.3791/51318 (2014).More

Rudick, R. A., Miller, D., Bethoux, F., Rao, S. M., Lee, J. C., Stough, D., Reece, C., Schindler, D., Mamone, B., Alberts, J. The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool. J. Vis. Exp. (88), e51318, doi:10.3791/51318 (2014).

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