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JoVE Journal Medicine

Manufacturing Chimeric Antigen Receptor T-Cells Using an Automated Cell Processor (Video) | JoVE

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Journal (Medicine)

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Taking the Next Step: a Neural Coaptation Orthotopic Hind Limb Transplant Model to Maximize Functional Recovery in Rat

Journal (Medicine)

Taking the Next Step: a Neural Coaptation Orthotopic Hind Limb Transplant Model to Maximize Functional Recovery in Rat

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Manufacturing Chimeric Antigen Receptor T-Cells Using an Automated Cell Processor (Video) | JoVE

Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

Article DOI: 10.3791/200476-v • 05:11 min • August 18th, 2023

August 18th, 2023 •

Rene Machietto¹, Nicholas Giacobbe¹, Jessica Perazzelli², Ted J. Hofmann², Allison Barz Leahy^2,3, Stephan A. Grupp^1,2,3, Yongping Wang^1,3,4, Stephan Kadauke^1,3,4

¹Cell and Gene Therapy Laboratory, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, ²Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia, ³Perelman School of Medicine at the University of Pennsylvania, ⁴Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia

Tags

Т-клетки химерного антигенного рецептора CAR-T-клетки иммунотерапия автоматизированный клеточный процессор CliniMACS Prodigy производство клеточной терапии закрытая система риск контаминации трансдукция Т-клеток вирусный вектор обогащение CD4+/CD8+ Т-клеток активация расширение сбор матрица активности настройка надлежащая производственная практика (cGMP) исследуемый новый лекарственный препарат (IND) тестирование выпуска

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