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JoVE Journal Medicine
Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents
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Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Article DOI: 10.3791/2558-v • 07:10 min • March 7th, 2011
March 7th, 2011 •
1, 1, 2, 1,3
1Department of Pathology, University of Alabama at Birmingham - UAB, 2Department of Radiology, University of Alabama at Birmingham - UAB, 3Department of Cell Biology and Neurobiology, University of Alabama at Birmingham - UAB

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A method for reliably grafting luciferase-tagged human malignant peripheral nerve sheath tumor cells into the sciatic nerve of immunodeficient mice is described. The use of bioluminescence imaging to demonstrate proper establishment of tumor grafts and criteria for random segregation of animals into study groups are also discussed.

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Orthotopic Xenografting Human Malignant Peripheral Nerve Sheath Tumor Cells In Vivo Testing Candidate Therapeutic Agents Animal Model Preclinical Trials Transgenic Mice Xenograft Models Immunodeficient Mice Therapeutic Ranges
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