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Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
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Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

DOI:
10.3791/52600-v

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10:05 min

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July 07, 2016

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, , , , , , ,
1Surgery,University of Minnesota, 2Biomedical Engineering,University of Minnesota, 3Medtronic, Inc., 4Bioengineering,Rice University, 5Pharmacy,University of Wisconsin

Chapters

  • 00:05Title
  • 02:07Preparations of the Swine
  • 02:27Preparatory Surgery
  • 05:15Determining Baseline Refractory Period
  • 05:46Determining Baseline AF Burden
  • 06:34Pericardial Drug Delivery and Post-Treatment Time-points
  • 06:55Heart Explantation
  • 08:16Reanimation and In Vitro Study Paradigm
  • 08:54Pericardial Administration of Docosahexaenoic Acid
  • 09:23Conclusion

Summary

Automatic Translation

Automatic Translation

We have developed a swine model for the target delivery of pharmacological agents within the pericardial space/fluid. Using this approach, the relative benefits of administered agents on induced atrial fibrillation, relative refractory periods and/or ischemic protection can be investigated.

Tags

Keywords: Pericardial DeliveryPharmacological AgentsCardiac ArrhythmiasIschemic DamageAtrial FibrillationCardiac SurgeryTransplantationSwine ModelRefractory PeriodCardioplegiaCardiac AnatomyPericardial FluidElectrophysiologic PropertiesCardiac DiagnosisCardiac Treatments

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