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挑战的药理功能磁共振成像:在临床前研究使用的5 - 羟色胺系统中的应用
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
Please note that all translations are automatically generated.
Click here for the English version.
挑战的药理功能磁共振成像:在临床前研究使用的5 - 羟色胺系统中的应用
DOI:
10.3791/3956-v
•
11:27 min
•
April 25, 2012
•
Anne Klomp
,
Jordi L. Tremoleda
,
Anouk Schrantee
,
Willy Gsell
,
Liesbeth Reneman
1
Department of Radiology, Brain Imaging Center
,
Academic Medical Center Amsterdam
,
2
Biological Imaging Centre, MRC Clinical Sciences Centre
,
Imperial College London
Chapters
00:05
Title
01:50
Preparing for
In vivo
MRI Imaging
03:15
In vivo
Imaging
05:40
Data Pre-processing
06:55
Data Analysis
09:28
Results: Pharmacological Challenge
10:44
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
这项技术的目的是评估5 - 羟色胺(5-HT)神经递质的功能,在生活和自由呼吸的动物药理磁共振成像(phMRI)和静脉注射一种选择性血清素再摄取抑制剂(SSRI),氟西汀挑战。
Tags
Pharmacological-challenge FMRI
Pre-clinical Research
5-HT System
Neurobiological Mechanisms
Drug Action
Neurotransmitter-related Disorders
Depression
ADHD
Imaging Methods
PET
SPECT
CT
Brain Disorders
Neuronal Connectivity
Clinical Investigations
Molecular Imaging Strategies
Spatial Resolution
Contrast-agent
Radio-labeled Molecules
Ionizing Radiations
Functional MRI
Psycho-motor Task
Adaptation Of FMRI
Specific Neurotransmitter System
Serotonin (5-HT)
Physiological Conditions
Pathological Conditions
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