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A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
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Medicine
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JoVE Journal Medicine
A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

English

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7,004 Views

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08:05 min

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November 08, 2019

DOI:

10.3791/60292-v

DOI:
10.3791/60292-v

•

08:05 min
November 08, 2019

•

9 Views
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1Department of Microsurgery,Jesús Usón Minimally Invasive Surgery Centre, 2Stem Cell Therapy Unit,Jesús Usón Minimally Invasive Surgery Centre, 3Animal Modelling Unit,Jesús Usón Minimally Invasive Surgery Centre

Summary

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Here, we describe a pre-clinical animal model for studying the pathophysiology of ischemia-reperfusion injury in reconstructive microsurgery. This free skin flap model based on the superficial caudal epigastric vessels in the rat may also allow for the evaluation of different therapies and compounds to counteract ischemia-reperfusion injury-related damage.

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Ballestín, A., Casado, J. G., Abellán, E., Vela, F. J., Campos, J. L., Martínez-Chacón, G., Bote, J., Blázquez, R., Sánchez-Margallo, F. M. A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery. J. Vis. Exp. (153), e60292, doi:10.3791/60292 (2019).

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