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1Department of Physiology and Pharmacology,Loma Linda University School of Medicine, 2College of Natural and Agricultural Sciences,University of California, Riverside , 3Department of Anesthesiology,Loma Linda University School of Medicine, 4Department of Neurosurgery,Loma Linda University School of Medicine
Chapters
- 00:00Title
- 02:15Apparatus
- 03:00Presurgical Preparations
- 04:17ICH Surgery
- 07:39Behavioral Assessment
- 08:59Representative Results
Modelos animais clinicamente relevantes de hemorragia intracerebral (ICH) são necessários para ampliar nosso conhecimento sobre AVC hemorrágico e para analisar novas estratégias terapêuticas. Neste estudo, descrever e avaliar dois modelos ICH que implementam injeções unilaterais de tanto sangue autólogo todo ou colagenase bacteriana no gânglio basal (corpo estriado) de camundongos.
Tags
ModelingIntracerebral HemorrhageMiceAutologous BloodBacterial CollagenasePreclinical ModelsTherapeutic StrategiesPathophysiologyHemorrhage InductionInjury ProgressionBlood Injection ModelCollagenase ModelBasal Lamina DisruptionPerihematomal EdemaNeurofunctional DeficitsDouble Injection ModelCD-1 MiceNeurofunctional DeficitsBrain Edema
