The experimental intracranial pressure-controlled blood shunt subarachnoid hemorrhage (SAH) model in the rabbit combines the standard procedures — subclavian artery cannulation and transcutaneous cisterna magna puncture, which enables close mimicking of human pathophysiological conditions after SAH. We present step-by-step instructions and discuss key surgical points for successful experimental SAH creation.
Andereggen, L., Neuschmelting, V., von Gunten, M., Widmer, H. R., Takala, J., Jakob, S. M., Fandino, J., Marbacher, S. The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects. J. Vis. Exp. (92), e52132, doi:10.3791/52132 (2014).