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Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke
 

Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke

Article doi: 10.3791/51291
February 4th, 2014

Summary February 4th, 2014

We have developed a brain slice model which can be used to examine molecular mechanisms involved in excitotoxicity-mediated brain injury. This technique generates viable mature brain tissue and reduces animal numbers required for experimentation, whilst keeping the neuronal circuitry, cellular interactions, and postsynaptic compartments partly intact.

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