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Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
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Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

Article DOI: 10.3791/52912-v • 11:24 min • July 3rd, 2015
July 3rd, 2015 •
1, 1, 1, 1, 1, 1
1Radiological Protection Research and Instrumentation, Canadian Nuclear Laboratories

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A protocol to evaluate changes in DNA damage levels and DNA repair capacity that may be induced by chronic in vivo low dose irradiation in mouse spleen lymphocytes, by measuring phosphorylated histone H2AX, a marker of DNA double-strand breaks, using flow cytometry is presented.

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Measuring DNA Damage DNA Repair Mouse Splenocytes Chronic In Vivo Exposure Low Doses Beta Radiation Gamma Radiation Biological Effects Environmental Safety Occupational Safety Public Health Safety Ionizing Radiation Chemical Substances Health Risks Cancer Protocol Spleen Cells DNA Double-strand Breaks Phosphorylated Histone H2AX DNA Repair Capacity Flow Cytometry Immunofluorescently Labeled H2AX Samples Double-strand Break Repair
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