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JoVE Journal
Medicine

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Intravenous Endotoxin Challenge in Healthy Humans
 

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Article doi: 10.3791/53913
May 16th, 2016

Summary May 16th, 2016

Intravenous administration of endotoxin reliably elicits dose-dependent physiological and immunological alterations consistent with several pathological states. This reductionist approach permits the investigation, modeling and experimental modification of systemic inflammation and its downstream effects in man.

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