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JoVE Journal Neuroscience
Bioluminescentie beeldvorming van ontstekingsprocessen in transgene muizen Na Perifere Enten van alfa-synucleine fibrillen
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Bioluminescentie beeldvorming van ontstekingsprocessen in transgene muizen Na Perifere Enten van alfa-synucleine fibrillen

Article DOI: 10.3791/55503-v • 09:32 min • April 13th, 2017
April 13th, 2017 •
1, 1, 1, 2, 2, 1
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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Perifere injectie van alfa-synucleine fibrillen in het peritoneum of de tong van Tg (M83 +/-: GFAP -Luc +/-) muizen, die humaan alfa-synucleine met familiaire A53T mutatie en vuurvlieg luciferase tot expressie brengen, kunnen neuropathologie induceren, waaronder neuroinflammatie in het centrale zenuwstelsel.

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Neuroscience alfa-synucleine bioluminescentie ontsteking synucleïnopathie neuroinvasion ziekte van Parkinson perifere prion-achtige prionoid
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