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JoVE Journal Neuroscience
Modelleren van Amyloid-β42 toxiciteit en neurodegeneratie in volwassen Zebrafish hersenen
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Modelleren van Amyloid-β42 toxiciteit en neurodegeneratie in volwassen Zebrafish hersenen

Article DOI: 10.3791/56014-v • 10:01 min • October 25th, 2017
October 25th, 2017 •
1, 2, 1, 1, 3, 2, 1,3
1German Centre for Neurodegenerative Diseases (DZNE) Dresden within Helmholtz Association, 2B CUBE, Center for Molecular Bioengineering, Technische Universität Dresden, 3Center for Regenerative Therapies Dresden (CRTD), TU Dresden

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Dit protocol beschrijft de synthese, karakterisering en injectie van monomeer amyloid-β42 peptiden voor het genereren van amyloïde toxiciteit in volwassen zebrafish om een model van de ziekte van Alzheimer, gevolgd door histologische analyses en detectie van samenvoegingen.

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Neurowetenschappen kwestie 128 Amyloid-β42 zebravis neurodegeneratie cerebroventricular microinjection ziekte van Alzheimer solid-phase peptide synthese
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