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Locomotorische beoordeling van 6-hydroxydopamine-geïnduceerde volwassen zebravis-gebaseerde Parkinson's Disease Model
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Locomotorische beoordeling van 6-hydroxydopamine-geïnduceerde volwassen zebravis-gebaseerde Parkinson's Disease Model

Article DOI: 10.3791/63355-v • 07:32 min • December 28th, 2021
December 28th, 2021 •
1, 1, 1,2, 1, 1, 2, 1
1Collaborative Drug Discovery Research (CDDR) Group and Brain Degeneration and Therapeutics Group, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam, 2Department of Medicine, Faculty of Medicine, Universiti Malaya

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Het huidige protocol beschrijft de intracerebroventriculaire (ICV) injectie van volwassen zebravissen met neurotoxische 6-hydroxydopamine (6-OHDA) bij het ventrale diencephalon (Dn) en de beoordeling van de aantasting en het daaropvolgende herstel van zwemgedrag postlesion met behulp van de open tank test, die vergezeld gaat van analyse met behulp van een video tracking software.

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