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Developmental Biology

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Kemiske Reversion af konventionelle humane pluripotente stamceller til en naiv-lignende tilstand med forbedret Multilineage differentiering potens
 
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Kemiske Reversion af konventionelle humane pluripotente stamceller til en naiv-lignende tilstand med forbedret Multilineage differentiering potens

Article doi: 10.3791/57921
June 10th, 2018

Summary June 10th, 2018

Please note that all translations are automatically generated.

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Vi præsenterer en protokol for effektiv, bulk og hurtige kemiske reversion af konventionelle afstamning-pulverlak humane pluripotente stamceller (hPSC) ind i en epigenomically-stabil naive præimplantations epiblast-lignende pluripotente tilstand. Denne metode resulterer i nedsat afstamning-pulverlak genekspression og markant forbedring i styret multilineage differentiering på tværs af et bredt repertoire af konventionelle hPSC linjer.

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