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JoVE Journal
Developmental Biology

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In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells
 

In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells

Article DOI: 10.3791/59359-v
April 25th, 2019

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Summary April 25th, 2019

We present here a protocol for the differentiation of human induced pluripotent stem cells into each somite derivative (myotome, sclerotome, dermatome, and syndetome) in chemically defined conditions, which has applications in future disease modeling and cell-based therapies in orthopedic surgery.

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