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Journal / Chemistry / 以波马利多米德为基础的人种-PROTACs对E3泛基金的化学灭活…
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以波马利多米德为基础的人种-PROTACs对E3泛基金的化学灭活
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以波马利多米德为基础的人种-PROTACs对E3泛基金的化学灭活

Article DOI: 10.3791/59472-v • 10:44 min • May 15th, 2019
May 15th, 2019 •
*1, *2, 1, 2, 2, 1
1Department of Internal Medicine III, University Hospital Ulm, 2Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
* These authors contributed equally

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这项工作描述了一种基于波马利多米德的合成和表征,即一种基于双功能的同质性PROTAC,作为诱导E3泛性联苯基雷布龙(CRBN)的泛化和降解的新方法,该物质是沙利度胺类比靶的目标。

Tags

化学 问题 147 CRBN PROTAC IMiD 波马利多米德 泛基丁连体 多发性骨髓瘤 蛋白酶体
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