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JoVE Journal
Immunology and Infection

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Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Article DOI: 10.3791/60645-v 08:50 min February 25th, 2020
February 25th, 2020



The use of an RNA-based approach to determine quantitative immune profiles of solid tumor tissues and leverage clinical cohorts for immune-oncology biomarker discovery is described through a molecular and informatics protocols.



Predictive Immune Modeling Solid Tumors Tumor Microenvironment Immuno-oncology Research RNA-based Health Expression Models Immune Cells Sensitive Measurements Specific Measurements Immune Contexture Multi-dimensional Biomarker Immunotherapies Immune Response Disease Progression Therapy Responses RNA Library Preparation Techniques Targeted Capture Wash Steps Quality Control Checkpoints Formalin-fixed Paraffin Embedded Samples First Strand Synthesis Reaction Thermal Cycler High-quality Intact RNA
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