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神经活性的光遗传学操作,调节自由移动小鼠的行为
JoVE Journal
Behavior
Author Produced
This content is Free Access.
JoVE Journal
Behavior
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
Please note that all translations are automatically generated.
Click here for the English version.
神经活性的光遗传学操作,调节自由移动小鼠的行为
DOI:
10.3791/61023-v
•
14:40 min
•
October 27, 2020
•
Laura Berg
2
,
Jill Gerdey
2
,
Olivia A. Masseck
2
1
Biology and Chemistry, Synthetic Biology
,
University of Bremen
,
2
Advanced Fluorescence Microscopy, Faculty of Biology and Biotechnology
,
Ruhr-Universität Bochum
Chapters
00:00
Introduction
00:59
Preparation of the Optical Implant
01:51
Injection and Implantation
06:01
Setting up a New Experiment in the Video Tracking Software
09:07
Open Field Experiment (Anxiety)
09:57
Barnes Maze (Learning)
10:47
Data Analysis (example Open Field)
12:21
Data Analysis (example Open Field): Statistics Program
13:23
Representative Results
13:52
Conclusion
Summary
Automatic Translation
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Automatic Translation
通过特定神经元群体或大脑区域的光遗传学操作,可以在自由移动的动物中以高时空分辨率改变行为。通过使用不同的光遗传学工具与慢性植入光纤相结合,可以执行各种神经元调制和行为测试。
Tags
Optogenetics
Neuronal Activity
Behavior
Freely Moving Mice
Optical Implant
Neuronal Modulation
Cell Type-specific
Neuronal Circuitry
Stereotactic Surgery
Anesthesia
Implantation
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