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Assessing Activity-based Anorexia in Mice
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JoVE Journal Behavior
Assessing Activity-based Anorexia in Mice

Assessing Activity-based Anorexia in Mice

DOI:
10.3791/57395-v

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08:26 min

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May 14, 2018

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, ,
1Department of Psychiatry,University of California, San Diego, 2University of California, Los Angeles

Chapters

  • 00:04Title
  • 00:41Set Up and Pre-experimental Acclimation Phase – Days 1 and 2
  • 03:13Experimental Baseline Phase – Days 3 to 9
  • 05:23Experimental Restriction Phase – Days 11 to 23
  • 06:39Results: Assessing Biochemical Consequences of Activity-based Anorexia
  • 07:44Conclusion

Summary

Automatic Translation

Automatic Translation

Mice individually housed with a running wheel while given limited access to food develop reductions in food consumption and increase activity on the running wheel. This experimental phenomenon is called activity-based anorexia. This paradigm provides an experimental tool for studying the neurobiology and behaviors underlying aspects of anorexia nervosa.

Tags

Keywords: Anorexia NervosaActivity-based AnorexiaMouse ModelNeurobiologyEating DisordersRunning WheelFood RestrictionBehavioral Assessment

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