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Modelar enfermedades neurodegenerativas asociadas a la edad en Caenorhabditis elegans
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Modelar enfermedades neurodegenerativas asociadas a la edad en Caenorhabditis elegans

Article DOI: 10.3791/61169-v • 07:04 min • August 15th, 2020
August 15th, 2020 •
1,2, 1,2
1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Greece, 2Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, 70013, Crete, Greece

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Aquí, introducimos y describimos metodologías ampliamente accesibles que utilizan algunos modelos versátiles de nematodos, incluyendo necrosis inducida por canales de iones hiperactivados y neurotoxicidad inducida por agregados de proteínas, para monitorear y diseccionar los fundamentos celulares y moleculares de las enfermedades neurodegenerativas asociadas a la edad.

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Biología Número 162 Envejecimiento A-sinucleína Muerte celular Ionestasis Necrosis Neurodegeneración Poliglutatión Proteostasis
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